Art

J-GLOBAL ID：201902214029682085   Reference number：19A2679812

Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells

ピレノシンAは単極紡錘体形成を誘導し,癌細胞の増殖を抑制する【JST・京大機械翻訳】

Author (17)： Myobatake Yusuke (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Kamisuki Shinji (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Tsukuda Senko (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Higashi Tsunehito (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Chinen Takumi (Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Takemoto Kenji (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Hachisuka Masami (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Suzuki Yuka (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Takei Maya (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Tsurukawa Yukine (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Maekawa Hiroaki (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Takeuchi Toshifumi (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Matsunaga Tomoko M. (Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan) ,  Sahara Hiroeki (School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan) ,  Usui Takeo (Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Matsunaga Sachihiro (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan) ,  Sugawara Fumio (Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 23  Page： Null  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Pyrenocine A, a phytotoxin, wa...

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Thesaurus term： cytotoxicity ,  image analysis ,  Structure-Activity Relationship ,  *spindle (cytology) ,  HeLa cell ,  in vitro experiment ,  enone ,  antitumor drug ,  Eg5 protein ,  Kinesin ,  M period ,  live cell ,  polynuclear aromatic hydrocarbon
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (4)： Natural products ,  Monopolar spindle ,  Anticancer drug ,  Mitotic arrest

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Monastrol ,  Pyrene

Terms in the title (6)： ピレノシンA ,  極 ,  紡錘体形成 ,  誘導 ,  癌細胞 ,  増殖