Watanabe Tsuyoshi

ワタナベツヨシ | Watanabe Tsuyoshi

Affiliation and department：
Job title：教授
Homepage URL (1)： http://www.asahikawa-med.ac.jp/dept/mc/anato2/

Research field (3)： Anatomy , Cell biology , Metabolism and endocrinology

Research keywords (9)： immunocytochemical techniques , immunocytochemistry , electron microscopy , Golgi apparatus , secretory granules , Hypothalamic pituitary gonadal axis , 電子顕微鏡技術 , ゴルジ装置 , 分泌顆粒

Research theme for competitive and other funds (13)：

2017 - 2020 余剰分泌顆粒のゆくえ:GnRH誘導体を活用した新規クリノファジー解析実験系の構築
2014 - 2017 Diversity in the global organization of the Golgi apparatus in differentiated secretory cells.
2010 - 2012 Characteristics in the overall organization and dynamics of the Golgi apparatus in the anterior pituitary endocrine cells.
2006 - 2008 Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes
2005 - 2007 Roles of the lipid raft-like microdomain in the secretory granule biogenesis within endocrine cells.

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Papers (38)：

Kawaguchi S, Okada M, Ijiri E, Koga D, Watanabe T, Hayashi K, Kashiwagi Y, Fujita S, Hasebe N. β3 adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism. Am J Physiol Heart Circ Physiol. 2019
Sato E, Maeda Y, Sato Y, Hinata A, Gomi H, Koga D, Torii S, Watanabe T, Hosaka M. Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes. Biochemical Journal. 2019. 476. 827-842
Hori JI, Koga D, Kakizaki H, Watanabe T. Differential effects of depot formulations of GnRH agonist leuprorelin and antagonist degarelix on the seminiferous epithelium of the rat testis. Biomedical Research. 2018. 39. 197-214
Koga D, Kusumi S, Watanabe T. Backscattered electron imaging of resin-embedded sections. Microscopy (Oxford, England). 2018
Maeda Y, Kudo S, Tsushima K, Sato E, Kubota C, Kayamori A, Bochimoto H, Koga D, Torii S, Gomi H, et al. Impaired Processing of Prohormones in Secretogranin III-Null Mice Causes Maladaptation to an Inadequate Diet and Stress. Endocrinology. 2018. 159. 2. 1213-1227

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MISC (14)：

WATANABE Tsuyoshi, SAKAI Yuko, HIRA Yoshiki, BOCHIMOTO Hiroki, HOSAKA Masahiro. Molecular and cellular basis for the secretory granule biogenesis in endocrine cells. Microscopy. 2008. 43. 1. 29-34
穂坂正博, 渡部剛, 内山安男, 竹内利行. 細胞内においてクロモグラニンAと結合する蛋白質の同定と解析. 日本細胞生物学会大会講演要旨集. 2001. 54回. 96-96
渡部剛, 和栗聡, 内山安男. 培養内分泌細胞におけるGreen Fluorescent Protein(GFP)標識グラニン蛋白の動態. 解剖学雑誌. 2000. 75. 1. 156-156
小池正人, 中西博, Saftig Paul, 井佐原京子, 大澤良之, 渡部剛, 和栗聡, 亀高諭, 山本健二, 木南英紀. 神経性セロイド様リポフスチン蓄積症(NCL)のモデル動物としてのカテプシンD欠損マウス. 解剖学雑誌. 2000. 75. 1. 117-117
渡部剛, 和栗聡, 内山安男. Green Fluorescent Protein(GFP)標識グラニン蛋白を発現させた培養内分泌細胞における分泌顆粒形成・放出過程の解析. 日本細胞生物学会大会講演要旨集. 1999. 52回. 45-45

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Lectures and oral presentations (8)：

ゴルジ装置の大局的構造と分泌動線から見た分泌細胞の類型化の試み
(日本解剖学会総会・全国学術集会講演プログラム・抄録集 2016)
Overall Shape of the Golgi Apparatus and Intracellular Organization of Secretory Cells: The Significance of the Spherical Golgi in the Pituitary Gonadotropes
(Gordon Research Conference: Protein Processing, Trafficking & Secretion 2014)
下垂体前葉におけるゴルジ装置構築の多様性:微小管構築との関連性に着目して
(日本解剖学会総会・全国学術集会講演プログラム・抄録集 2013)
AtT-20細胞におけるセクレトグラニンIII(SgIII)の発現抑制はトランスゴルジネットワーク(TGN)の空胞化と調節性分泌の部分的障害を誘起する。
(解剖学雑誌 2012)
哺乳動物の内分泌細胞におけるゴルジ装置の構築と分泌経路の特徴
(日本顕微鏡学会第53回シンポジウム生物系セッション「電子顕微鏡の多様な生物応用」 2009)

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Education (2)：

1985 - 1989 University of Tsukuba
1979 - 1985 University of Tsukuba School of Medicine

Professional career (1)：

Ph.D., M.D. (University of Tsukuba)

Work history (3)：

2000/10 - 現在 Asahikawa Medical University
1995/05 - 2000/09 Osaka University Faculty of Medicine
1989/04 - 1995/05 University of Tsukuba Institute of Basic Medical Sciences Asociate Professor

Association Membership(s) (3)：

日本顕微鏡学会 , 日本細胞生物学会 , 日本解剖学会

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