Rchr
J-GLOBAL ID：200901090375260961
Update date: Apr. 17, 2024
Takao Toshifumi
タカオ トシフミ | Takao Toshifumi
Affiliation and department：
Job title：
Professor
Research field (1)：
Structural biochemistry
Research theme for competitive and other funds (30)：
- 2022 - 2025 尿中蛋白質断片の網羅的解析による日和見感染症の新規診断法の開発
- 2017 - 2022 Molecular dissection of robust and flexible circadian clock and its control animal physiology
- 2014 - 2017 Regulation of membrane traffic of Wnt and its receptors
- 2013 - 2017 Studies on the physiological role of Prx4 in oxidative protein folding
- 2011 - 2015 Amino acid sequence analysis of fossil proteins using mass spectrometry
- 2011 - 2014 Development of tissue peptidome analysis technology and its application to discovery of new biologically active peptides
- 2011 - 2013 Selective activation of Wnt signaling pathway using with purified Wnt proteins
- 2010 - 2012 Mass Spectrometry of Metalloproteins and High-Molecular-Weight Protein Complexes
- 2010 - 2011 A novel drug carrier based on the collagen-like triple-helical peptide
- 2006 - 2010 Structural basis of functional coupling between transcription and cellular metabolism
- 2007 - 2008 Diagnostic system for acute cellular rejection in livertransplantation using protemomic analysis of bile
- 2003 - 2007 Molecular machinery regulating energy and metabolic networks in plant cells
- 2003 - 2005 植物細胞エネルギー・代謝ネットワークを制御する分子マシナリー
- 2003 - 2004 質量分析法によるリガンド-レセプター相互作用の精密解析
- 2002 - 2003 Dynamism analysis of posttranslational modifications by mass spectrometry.
- 2000 - 2001 Development of the method for high-sensitivity structural analysis of carbohydrate moieties of a glycoprotein by mass spectrometry
- 2000 - 2000 プロテオーム研究の国際的動向と将来展望に関する調査研究
- 1998 - 1999 Development of a high-energy collision-induced dissociation device for high-sensitivity and high-resolution MS/MS/MS
- 1996 - 1997 Development of a Full-Automatic Equipment for Gas-Phase Chemical Reaction Intended for Microanalysis of Protein Primary Structures
- 1994 - 1995 Capillary HPLC/electrospray ionization mass spectrometry for structural analysis of micro-quantities of proteins
- 1993 - 1993 質量分析による糖蛋白質糖鎖構造の解析法に関する研究
- 1992 - 1993 A New Pulsed FAB Control System Coupled with an Array Detector on a Four-Sector Tandem Mass Spectrometer
- 1990 - 1991 A Control System for a Four-Sector Tandem Mass Spectrometer
- 1988 - 1988 質量合析による遺伝子組換え蛋白質の構造解析法に関する研究
- プロテオミクス関連装置の開発
- 高感度・高出力質量分析計の開発
- 質量分析による蛋白質の構造解析
- Development of proteomic apparatus
- Development of high-sensitivity and high-throughput mass spectrometer
- Structural Analysis of Proteins by Mass Spectrometry
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Papers (106)：
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Luis Javier González, Satomy Pousa, Hironobu Hojo, Shio Watanabe, Daisuke Higo, Alina Rodriguez Mallon, Toshifumi Takao. Differentiation of isobaric cross-linked peptides prepared via maleimide chemistry using MALDI-MS and MS/MS. Rapid Communications in Mass Spectrometry. 2023. 38. 2
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櫻井 航輝, Li Li, Pan Pan, Wang Qiuyi, 高尾 敏文, 疋田 貴俊. LC-MS/MSによる多発性硬化症モデルマウスにおける脱髄・炎症関連ニューロステロイドの探索. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 153-153
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Kota Nomura, Ryo Okamoto, Yuta Maki, Ayumu Hayashibara, Toshifumi Takao, Tomoya Fukuoka, Eiji Miyoshi, Bradley L Pentelute, Yasuhiro Kajihara. Rapid Chemical Synthesis of Serine Protease Inhibitor Kazal-type 13 (SPINK13) Glycoform by a Combined Method with Glycan Insertion Strategy and Fast-Flow Fmoc SPPS. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. 29. 42. e202300646
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Huibin Zhu, Mone Kurokawa, Mengyao Chen, Qiuyi Wang, Masayuki Inoue, Toshifumi Takao. Characteristic fragmentation of polyunsaturated fatty acids with allylic vicinal diols in positive-ion LC/ESI-MS/MS. Journal of lipid research. 2023. 64. 6. 100384-100384
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Takuma Kozono, Chifuyu Jogano, Wataru Okumura, Hiroyuki Sato, Hitomi Matsui, Tsubasa Takagi, Nobuaki Okumura, Toshifumi Takao, Takashi Tonozuka, Atsushi Nishikawa. Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via IP3 receptors. Journal of Cell Science. 2023. 136. 4
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MISC (169)：
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HOJO Hironobu, TAKEI Toshiki, ASAHINA Yuya, OKUMURA Nobuaki, TAKAO Toshifumi, SO Masatomo, SUETAKE Isao, SATO Takeshi, KAWAMOTO Akihiro, HIRABAYASHI Yoshio. CHEMICAL SYNTHESIS OF MEMBRANE PROTEIN CAVEOLIN AND ITS MEMBRANE INSERTION. ペプチド討論会講演要旨集. 2020. 57th
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清水 貴美子, 前畑 佳納子, 池野 知子, Qiuyi Wang, 高尾 敏文, 深田 吉孝. 行動を制御する脳内分子メカニズムとそのダイナミクス 記憶の概日変動を生み出す分子制御メカニズム. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3S11m-01]
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大野泉, 光永修一, 菅元康, 池田公史, 坪内拡伸, 柳重久, 奥村宜明, 高尾敏文, 中里雅光. 新たな早期膵癌診断マーカーとしての尿中キニノーゲン(KNG)断片の可能性. 膵臓(Web). 2019. 34. 3. A260-A261(J-STAGE)-A261
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N. Itai, R. Okabe, T. Shimazu, T. Takao, Y. Kaburagi, T. Dohi, T. Tonozuka, A. Nishikawa. Phosphorylation of sorting nexin 5 regulates vesicular trafficking. MOLECULAR BIOLOGY OF THE CELL. 2015. 26
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貝森 淳哉, 前原 一満, 畑中 雅喜, 小尾 佳嗣, 津田 秀年, 山本 聡子, 市丸 直嗣, 楽木 宏実, 高原 史郎, 大川 恭行, et al. 抑制性ヒストンアセチル化修飾H4K20acはGcn5によって制御され、臓器肥大により誘導される. 日本腎臓学会誌. 2014. 56. 3. 415-415
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Books (15)：
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蛋白質・核酸・酵素"蛋白質の質量分析(1)磁場型質量分析装置とその応用"
共立出版 2000
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プロテオーム解析法(実験医学別冊)"De novo sequencingのための解析ソフトウェア"
羊土社 2000
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Mass spectrometry of a protein(1) : Magnetic sector mass spectrometer and its application
2000
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Software aid for de novo sequencing
2000
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質量分析計による分子量の精密測定。
秀潤社 1998
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Lectures and oral presentations (1)：
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Active ternary complex of ribonuclease HI: RNA/DNA hybrid: metal ions probed by ESI mass
(2022)
Works (5)：
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植物細胞エネルギー・代謝ネットワークを制御する分子マシナリー
2004 -
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質量分析法によるイネ組織・時期特異的超微量タンパク質の解析及び翻訳後修飾情報(糖タンパク質)の構造解析
2000 -
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Proteomic analysis of rice proteins and their post-translational modifications(such as glycosylation)in different tissues or under different conditions by mass spectrometry
2000 -
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質量分析法による生体内ペプチドの超微量構造解析に関する研究
1999 -
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Research on structural analysis of biological peptides by mass spectrometry
1999 -
Education (4)：
- - 1986 Osaka University
- - 1986 Osaka University Graduate School, Division of Natural Science
- - 1981 Osaka University School of Science
- - 1981 Osaka University Faculty of Science
Professional career (1)：
- (BLANK) (Osaka University)
Work history (4)：
- 1987 - 1996 Osaka University Institute for Protein Research
- 1987 - 1996 Osaka University, Institute for Protein Research, Instructor
- 1996 - - 大阪大学蛋白質研究所 助教授
- 1996 - - Osaka University, Institute for Protein Research, Associate Professor
Awards (3)：
- 2022/11 - from the University of Havana Dr. Honoris Causa
- 1994 - 日本生化学会奨励賞
- 1992 - 内藤記念科学奨励金
Association Membership(s) (5)：
日本質量分析学会
, 日本ペプチド学会
, アメリカ質量分析学会(The American Society for Mass Spectrometry)
, 日本生化学会
, 日本化学会
