Rchr
J-GLOBAL ID：200901093035023050
Update date: Nov. 16, 2024
Hironobu Hojo
ホウジョウ ヒロノブ | Hironobu Hojo
Affiliation and department：
Homepage URL (1)：
http://www.protein.osaka-u.ac.jp/organic/index.html
Research field (3)：
Bioorganic chemistry
, Structural/physical organic chemistry
, Molecular biochemistry
Research keywords (2)：
生物有機化学
, Biological Organic Chemistry
Research theme for competitive and other funds (22)：
- 2022 - 2025 タンパク質の構造をとらない領域 の運動性・機能の解析
- 2022 - 2025 Chemical synthesis and fuctional analysis of lipidated histone
- 2020 - 2023 基質糖化に起因した歯髄の異所性石灰化メカニズムの解明と臨床応用法の開発
- 2020 - 2022 抗原を認識する環状ペプチドの効率的な同定法の開発と検査試薬への応用
- 2016 - 2019 Elucidation of the glycated collagen reaction in dentin and its application to next dental treatment
- 2016 - 2019 Chemical synthesis of caveolin
- 2013 - 2015 プラズマ照射による糖鎖誘導体の構造変化解析とプラズマ医療への応用
- 2011 - 2014 Carbohydrate recognition mechanisms of galectins and carbohydrate processing enzymes deduced from X-ray structures
- 2011 - 2014 Synthesis of complex-type glycan containing LacdiNAc structure and its application to the glycoprotein synthesis
- 2008 - 2010 Development of a synthetic method for hydrophobic glycoprotein and its application to saposin synthesis
- 2006 - 2007 In vitro folding of synthetic glycoprotein
- 2004 - 2005 A breakthrough to the microheterogeneity of the carbohydrate structure in glycoprotein by synthetic approach
- 2002 - 2003 Synthesis of novel cyclodextrin derivatives and its application to search for the inhibitor of H.pyroli growth
- 2001 - 2003 Synthetic studies on the functional glycopeptide conjugates
- 1999 - 2000 I型コラーゲンの細胞接着部位を有するモデルペプチドの合成と人工皮膚への応用
- 1999 - 2000 Synthetic studies on the unnatural glycan-linked dolichylpyrophosphates
- 1997 - 1998 ヘリコバクター・ピロリ感染による胃潰瘍の新規治療薬の開発
- 1996 - 1997 Development of design method to get soluble protein
- 1996 - 1996 スカベンジャー受容体活性部位を用いた血液浄化材料の開発
- 1994 - 1995 Method for protein design based on module units.
- 1993 - 1993 RNAポリメラーゼ中に存在するRNA分解酵素様ドメインの合成化学的研究
- 1992 - 1993 Inprovement of Thioester Method and Synthesis of Cysteine-Containing Proteins
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Papers (165)：
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Masatomo So, Misaki Ono, Shigeki Oogai, Minako Kondo, Kaede Yamazaki, Charlotte Nachtegael, Hiroshi Hamajima, Risa Mutoh, Masaki Kato, Hisaya Kawate, et al. Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils. Bioscience, Biotechnology, and Biochemistry. 2024
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Ying He, Toshiki Takei, Luis Moroder, Hironobu Hojo. Unexpected diselenide metathesis in selenocysteine-substituted biologically active peptides. Organic & Biomolecular Chemistry. 2024
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Akina Yamada, Toshiki Takei, Toru Kawakami, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Hironobu Hojo. Application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement. Frontiers in Chemistry. 2024. 12
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Yasuhito Akai, Yuya Asahina, Hironobu Hojo. The dipicolylamino group as an efficient leaving group for amide bond formation via hexafluoroisopropyl ester. Organic and Biomolecular Chemistry. 2024. 22. 8. 1699-1707
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Luis Javier González, Satomy Pousa, Hironobu Hojo, Shio Watanabe, Daisuke Higo, Alina Rodriguez Mallon, Toshifumi Takao. Differentiation of isobaric cross-linked peptides prepared via maleimide chemistry using MALDI-MS and MS/MS. Rapid Communications in Mass Spectrometry. 2023. 38. 2
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MISC (155)：
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Ramos-bermúdez, Pablo E, Satomy Pousa, Paulo Carvalho, Rodrigo Soares, Caldeira Bran, Batista, Michel, Hojo, Hironobu, Garay, Hilda E, et al. A hydrolyzed N-propionylthiosuccinimide linker is cleaved by metastable fragmentation, increasing reliability of conjugation site identification in conjugate vaccines. Rapid Commun Mass Spectrom. 2024. 38. e9859
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Hojo H, Nakatani F, Suetake I. Synthesis and Functional Study of Palmitoylated Histone Protein, Proceedings of the 36th European Peptide Symposium. European Peptide Society, 2022. 2022
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Nakano Mikito, Hanashima Shinya, Hara Toshiaki, Hara Toshiaki, Kabayama Kazuya, Asahina Yuya, Hojo Hironobu, Komura Naoko, Komura Naoko, Ando Hiromune, et al. FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers. Biochimica et Biophysica Acta. 2021. 1863. 8
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二村友香, 樺山一哉, 樺山一哉, 樺山一哉, 朝比奈雄也, 花島慎弥, 北條裕信, 深瀬浩一, 深瀬浩一, 深瀬浩一. Interaction analysis of transmembrane peptide of insulin receptor with ganglioside GM3. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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HOJO Hironobu, TAKEI Toshiki, ASAHINA Yuya, OKUMURA Nobuaki, TAKAO Toshifumi, SO Masatomo, SUETAKE Isao, SATO Takeshi, KAWAMOTO Akihiro, HIRABAYASHI Yoshio. CHEMICAL SYNTHESIS OF MEMBRANE PROTEIN CAVEOLIN AND ITS MEMBRANE INSERTION. ペプチド討論会講演要旨集. 2020. 57th
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Books (2)：
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Chemical synthesis of glycopeptides and glycoproteins in Synthetic Glycomes (W. Guan, L. Li, P. G. Wang Eds.)
Royal Society of Chemistry 2019 ISBN:9781788011648
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Chemical synthesis of glycoproteins by the thioester method in Chemical Ligation (L. D. D'Andrea, A. Romanelli Eds.)
Wiley 2017 ISBN:9781119044109
Lectures and oral presentations (1)：
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Investigation on stereochemistry of cysteinyl prolyl ester (CPE) peptide for the formation of thioester
(The 57th Japanese Peptide Symposium 2020)
Professional career (2)：
- (BLANK) (Osaka University)
- (BLANK) (Osaka University)
Work history (3)：
- - 2013/10 Osaka University Institute for Protein Research
- - 2003/04 Tokai University School of Engineering
- 1998/10 - 2003/03 Tokai University School of Engineering
Awards (1)：
Association Membership(s) (4)：
日本糖質学会
, 日本農芸化学会
, 日本化学会
, 日本ペプチド学会
