Research field (2)：
Biophysics
, Basic physical chemistry
Research keywords (7)：
Solid-state NMR
, NMR
, Protein
, Biophysics
, 蛋白質
, 核磁気共鳴
, 生物物理学
Research theme for competitive and other funds (33)：
2021 - 2024 Multi-scale structural analysis of membrane protein in cells by hyperpolarized NMR
2014 - 2018 In situ Protein NMR Structure Analysis
2014 - 2018 Site selective cellular analysis by solid-state NMR
2014 - 2016 Protein NMR method developed for macromolecular complex
2012 - 2014 New NMR methods developed for structure determination of large proteins
2011 - 2014 NMR live imaging technology to monitor membrane protein structure
2011 - 2013 高磁場動的核分極固体NMRの生体系応用法の開発
2010 - 2011 変性構造転移による膜蛋白質シグナル伝達機構の固体NMRによる解明
2009 - 2011 Understanding the mechanism of amyloid fibrillation on the basis of single fibril and real-time observation
2007 - 2009 Solid-state NMR analysis of membrane protein complexes with 7-transmembrane helices
2007 - 2008 脂質二重膜にある蛋白質ナノ複合体の固体NMRによる原子分解能構造解析
2003 - 2008 Intermolecular soft interactions regulating H^+-ATPsynthase function
2002 - 2004 Rotary catalysis mechanism of H^+-ATP synthase investigated by novel NMR methodology
2001 - 2002 F_0F_1-ATP合成酵素サブユニットcの固体NMR法による構造決定
1999 - 2000 F_0F_1-ATP合成酵素サブユニットcの固体NMR法による構造解析
2000 - Structural analysis by solid state nuclear magnetic resonance
2000 - 固体核磁気共鳴法による蛋白質構造解析
1998 - 1999 Structure and functions of a very small tetraheme protein -Molecular mechanism of bioremediation-
1997 - 1999 Structure-Function Analysis of HィイD1+ィエD1-ATP Synthase by Solution and Solid State NMR
1997 - 1999 Development of Solid-State NMR Method for Studying Higher-Order Structure of Proteins
1998 - 1998 NMRによるヒトリゾチームの変性構造解析
1997 - 1997 NMRによるリゾチーム非天然構造の比較
1994 - 1997 Development of Novel Methods for Structural Analyses of Proteins
1996 - 1996 リゾチームの塩酸グアニジン変性構造の解析
1995 - 1995 リゾチームの塩酸グアニジン変性構造の解析
1994 - 1994 生体高分子構造解析の国体NMRによる二面角決定法の開発
創薬等ライフサイエンス研究のための相関構造解析プラット フォームによる支援と高度化
solid-state nuclear magnetic resonance for biological systems
Development of Solid-State NMR Spectroscopy for Determing Molecular Structure
Study of Protein Structure and Function by Solid-State NMR
生体系固体核磁気共鳴
分子構造決定のための固体NMR法の開発
固体NMRによる蛋白質の構造と機能の研究
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Papers (229)：
Xin Zhang, Hajime Tamaki, Takashi Kikukawa, Toshimichi Fujiwara, Yoh Matsuki. Structural changes of Natronomonas pharaonis halorhodopsin in its late photocycle revealed by solid-state NMR spectroscopy. Biophysical chemistry. 2024. 315. 107329-107329
Yasuto Todokoro, Yoshiyuki Miyasaka, Hiromasa Yagi, Masatsune Kainosho, Toshimichi Fujiwara, Hideo Akutsu. Structural analysis of ATP bound to the F1-ATPase β-subunit monomer by solid-state NMR- insight into the hydrolysis mechanism in F1. Biophysical chemistry. 2024. 309. 107232-107232
Kazuya Nagano, Tomohiro Nakao, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Michiko Nakamura, Naoki Imakawa, Ayako Egawa, Toshimichi Fujiwara, Jian Qing Gao, et al. Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin. Food Chemistry. 2024. 437. Pt 2. 137866-137866
Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Tatsumi-Koga, et al. Design of complicated all-α protein structures. Nature Structural and Molecular Biology. 2024. 31. 2. 275-282
板坂佑真, 小篭蒼, 古板恭子, 杉木俊彦, 若松馨, 内田紀之, 石田康博, 相田卓三, 藤原敏道, 児嶋長次郎, et al. Development of RDC measurement method for protein using titanium oxide nanosheets and non-detergent sulfobetaines. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
櫻林修平, 櫻林修平, 古板恭子, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎, 児嶋長次郎. DNA recognition mechanism of naphthyridine dimer, a CGG repeat-binding drug, analyzed by NMR. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
13C-13C Distance Measurements by Polarization Transfer Matrix Analysis of 13C Spin Diffusion in Uniformly 13C-labeled Molecular Complex under Magic-angle Spinning
Royal Society of Chemistry 2014
Isotope labeling and NMR spectroscopy of proteins
Kagaku Doujin 2009
Isotope labeling and NMR spectroscopy of proteins
Kagaku Doujin 2009
タンパク質の同位体ラベルとNMR分光法
化学同人 2009
Structural analysis of membrane systems by solid-state NMR. in Chemistry, Physics, and Biology in Macromolecular Science
Osaka University Press 2008
1980 - 1985 Osaka University Graduate School of Science Department of Chemistry
1976 - 1980 Osaka University School of Science Department of Chemistry
Professional career (2)：
Doctor of Science (Osaka University)
Doctor of Science
Work history (7)：
2023/04 - 現在 Osaka University Professor Emeritus
2008/04 - 2023/03 Osaka University Institute for Protein Research professor
2007 - 2008 Osaka University Institute for Protein Research
2000 - 2007 Osaka University Institute for Protein Research Associate Professor
1996/01 - 2000/12 横浜国立大学 工学部 物質工学科 助教授
1992/04 - 1996/01 Yokohama National University
1985/04 - 1992/04 JEOL Biometrology Lab
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Committee career (5)：
2021/12 - 現在 International Society of Magnetic Resonance Fellow
2022/04 - 2024/03 Nuclear Magnetic Resonance Society of Japan President
2008/04 - 2024/03 Nuclear Magnetic Resonance Society of Japan Administration officer
2018/04 - 2020/03 Osaka University Aide to University President
2013/04 - 2014/03 Osaka University Chairperson of committee for human rights issues
Awards (1)：
2019/11 - The Society of Electron Spin Science and Technology Development of high sensitivity magic-sample spinning NMR by dynamic nuclear polarization
Association Membership(s) (9)：
The Society of Electron Spin Science and Technology
, International Society of Magnetic Resonance
, The Chemical Society of Japan
, 電子スピンサイエンス学会
, International Society of Magnetic Resonance
, 日本核磁気共鳴学会
, 日本蛋白質科学会
, 日本化学会
, 日本生物物理学会
