Rchr
J-GLOBAL ID：200901094952584750   Update date: Jun. 19, 2025

Shinohara Akira

シノハラ アキラ | Shinohara Akira
Affiliation and department：
Osaka University Institute for Protein Research

About Osaka University Institute for Protein Research


Job title： Professor
Homepage URL  (1)： http://www.protein.osaka-u.ac.jp/genome/index.html
Research field  (2)： Molecular biology ,  Genetics
Research keywords  (1)： 分子生物学
Research theme for competitive and other funds  (34)：
  • 2019 - 2022 Molecular mechanisms of control of recombination by dynamics of RAD51/DMC1-DNA complexes
  • 2015 - 2020 Chromosome OS
  • 2015 - 2020 Control of chromosome functions by axis-loop structure (chromosome 3D) during meiosis
  • 2016 - 2019 Molecular mechanism of partner choice for recombination by two RecA homologs
  • 2014 - 2016 Functions of nuclear actin filament and its mechanism of the formation
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Papers (98)：
  • Sheetal Paliwal, Partha Dey, Swarangi Tambat, Akira Shinohara, Gunjan Mehta. Role of ATP-dependent chromatin remodelers in meiosis. Trends in Genetics. 2025. 41. 3. 236-250
  • Chin-Dian Wei, Hao-Yen Chang, Chia-Hua Lu, Chih-Chun Chang, Asako Furukohri, Stephen Mwaniki, Akira Shinohara, Peter Chi, Hung-Wen Li. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA. Nucleic Acids Research. 2024. 52. 19. 11768-11784
  • Stephen Mwaniki, Priyanka Sawant, Osaretin P. Osemwenkhae, Yurika Fujita, Masaru Ito, Asako Furukohri, Akira Shinohara. Mutational analysis of Mei5, a subunit of Mei5-Sae3 complex, in Dmc1-mediated recombination during yeast meiosis. Genes to Cells. 2024. 29. 8. 650-666
  • Arivarasan Sampathkumar, Zhong Chen, Yuting Tang, Yurika Fujita, Masaru Ito, Akira Shinohara. Replication protein-A, RPA, plays a pivotal role in the maintenance of recombination checkpoint in yeast meiosis. Scientific Reports. 2024. 14. 1. 9550
  • Kenichiro Matsuzaki, Akira Shinohara, Miki Shinohara. Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation. Nucleic Acids Research. 2024. 52. 10. 5774-5791
ｍore...
MISC (54)：
  • Mwaniki, S.W, Sawant P, Osenwankhae O, Ito, M, Fujita, Y, Furukohori, A, Shinohara A. Post-translational cleavage of Mei5 of Dmc1 mediator, Mei5-Sae3, in yeast meiosis. Genes to Cells. 2024. accepted
  • Li W, Zhang L, Shinohara A, Keeney S. Editorial: Meiosis: From Molecular Basis to Medicine. Frontier in Cellularl and Developmental Biology. 2021. 9. 812292
  • G.N. Krishnaprasada, V.P. Ajith, Shinohara, M, Chakraborty, P, Lin, G. Steinmetz, L.M, Shinohara, A, Nishant K.T. The baker’s yeast Msh4-Msh5 binds to double-strand break hotspots distant to chromosome axis to promote crossovers. BioRxiv. 2020
  • Tomoko Takagi, Masako Osumi, Akira Shinohara. Nuclear actin cable with multiple branches during yeast meiosis. BioRxiv. 2019
  • Challa Kiran, Miki Shinohara, Akira Shinohara. Prophase pathway of arm-cohesin removal in budding yeast meiosis. GENES & GENETIC SYSTEMS. 2014. 89. 6. 278-278
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Lectures and oral presentations  (20)：
  • Fignl1 AAA+ ATPase modulates the dynamics of Rad51 and Dmc1 ensembles
    (Chromosome stability 2022 2022)
  • 減数分裂期のDNA交換と 染色体構造形成の制御のメカニズム
    (神戸大学理学部生物科学科セミナー 2022)
  • Fignl1 AAA+ ATPase modulates the dynamics of Rad51 and Dmc1 ensembles
    (FASEB meeting on recombination and genome rearrangement 2022)
  • Control of homologous recombination during meiosis and mitosis
    (ANSC Reproductive Physiology, University of Illinois at Urbana-Champaign Urbana, USA 2022)
  • Human RAD51 paralog, SWSAP1, promotes RAD51 assembly by regulating the anti-recombinase, FIGNL1 AAA+ ATPase
    (Seminar at IISER Thiruvananthapuram 2019)
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Works (12)：
  • 減数分裂期染色体機能部位におけるプロテインプロファイリング
    2004 -
  • 減数分裂期組換えと生殖細胞形成
    2004 -
  • 相同組換えによるゲノム安定化を介した発ガンの防御
    2004 -
  • 真核生物の相同組換えの分子メカニズムの解明
    2004 -
  • 酵母Rad52蛋白質の生化学的解析
    1990 - 1993
ｍore...
Education (5)：
  • 1988 - 1991 Osaka Univ. Graduate School of Science
  • - 1991 Osaka University Graduate School, Division of Natural Science
  • 1986 - 1988 Osaka University Graduate School of Science
  • 1982 - 1986 Osaka Univ. School of Science Department of Biology
  • - 1986 Osaka University Faculty of Science
Professional career (2)：
  • Ph.D. (Osaka University)
  • (BLANK)
Work history (9)：
  • 2001 - 2003 大阪大学院理学研究科 助教授
  • 2003 - - 大阪大学たんぱく質研究所 教授
  • 2001 - - Osaka Univ. Graduate School of Science, Assistant Prof.
  • 1999 - 2000 シカゴ大学 準教授
  • 1999 - 2000 University of Chicago, Assistant Professor
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Awards (3)：
  • 2021/04 - Awards for Science and Technology Study on molecular mechanism of homologous recombination
  • 2009 - 大阪市 大阪府 大阪科学技術センター 大阪科学賞
  • 1992 - 日本分子生物学会 東燃研究奨励賞
Association Membership(s) (1)：
日本分子生物学会
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