MORI Takashi

Affiliation and department：
Job title： Professor
Research theme for competitive and other funds (11)：

2023 - 2026 Elucidation of signal transduction of the gastrointestinal peptide Betagenin and its application to diabetes treatment.
2022 - 2025 Alzheimer’s disease: Establishment of innovative peptide therapy targeting apolipoprotein E
2020 - 2024 FISH に頼らない高悪性度B細胞リンパ腫の診断法の確立とその分子基盤
2014 - 2018 アルツハイマー病:食物由来のβーアミロイド蛋白抑制物質の併用療法と環境療法の探索
2010 - 2014 Development of a new therapeutic strategy for Alzheimer's disease: Exploration of amyloid-beta inhibitors derived from foods and environment enrichment therapy.

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Papers (32)：

Darrell Sawmiller, Naoki Koyama, Masakazu Fujiwara, Tatsuya Segawa, Masahiro Maeda, Takashi Mori. Targeting Apolipoprotein E and N-terminal Amyloid β-protein Precursor Interaction Improves Cognition and Reduces Amyloid pathology in Alzheimer mice. Journal of Biological Chemistry. 2023. 299. 7. 104846
Takashi Mori, Naoki Koyama, Tomotaka Yokoo, Tatsuya Segawa, Masahiro Maeda, Darrell Sawmiller, Jun Tan, Terrence Town. Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice. Journal of Biological Chemistry. 2020. 295. 48. 16251-16266
Darrell Sawmiller, Ahsan Habib, Huayan Hou, Takashi Mori, Anran Fan, Jun Tian, Jin Zeng, Brian Giunta, Paul R. Sanberg, Mark P. Mattson, et al. A novel apolipoprotein E antagonist functionally blocks apolipoprotein E interaction with N-terminal amyloid precurcor protein, reduces β-amyloid-associated pathology, and improves cognition. Biological Psychiatry. 2019. 86. 3. 208-220
Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town. Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice. Journal of biological Chemystry. 2019. 294. 8. 2714-2731
Ahsan Habib, Huayan Hou, Takashi Mori, Jun Tian, Jin Zeng, Shengnuo Fan, Brian Giunta, Paul R. Sanberg, Darrell Sawmiller, Jun Tan. Human umbilical cord blood serum-derived α-secretase: Functional testing in Alzheimer's disease mouse models. Cell Transplant. 2018

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Lectures and oral presentations (37)：

アポリポ蛋白E-アミロイド前駆体蛋白結合を標的としたアルツハイマー病の新規治療法
(第42回日本認知症学会学術集会 2023)
アポリポ蛋白E-アミロイド前駆体蛋白結合を標的としたアルツハイマー病の治療法の開発
(第70回日本実験動物学会 2023)
Combined beneficial actions of gallic acid remediate Alzheimer pathology and restore cognition in mice.
(Neuroscience 19 2019)
Immune checkpoint inhibition induce activated dendritic cell infration in PD-L1 negative tumor in mouse neuroblastoma model.
(50th Congress of the Internatinal Society of Paediatric Oncology 2018)
Combination therapy with (-)-epigallocatechin-3-gallate and ferulic acid effectively modifies Alzheimer-like pathology.
(Neuroscience 17 2017)

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Professional career (1)：

博士(獣医学) (日本獣医生命科学大学)

Committee career (1)：

1996/04 - 現在日本脳循環代謝学会評議員

Association Membership(s) (7)：

The American Society for Biochemistry and Molecular Biology , Member of the Society for Neuroscience (Washington, U.S.A.) , 日本認知症学会 , 日本脳循環代謝学会 , 日本獣医病理学専門家協会 , 日本獣医病理学会 , 日本獣医学会

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