Noritaka Hashii

ハシイノリタカ | Noritaka Hashii

Affiliation and department：
Homepage URL (1)： http://www.nihs.go.jp/index-j.html

Research field (6)： Pharmacology , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development , Structural biochemistry , Biochemistry , Analytical chemistry

Research keywords (7)：包括脳ネットワーク , 高次構造 , 糖タンパク質 , プロテオミクス , グライコミクス , 質量分析 , 糖鎖

Research theme for competitive and other funds (10)：

2024 - 2027 体内分布や抗原提示に着目したFcRn親和性改変抗体間の違いに関する研究
2021 - 2024 MAPPs解析によるFcRn親和性の変化が抗原提示に及ぼす影響の解明
2017 - 2019 HLAの関与する解熱鎮痛薬誘因性重症薬疹の初期発症メカニズムの解明
2015 - 2018 Basic research on neonatal Fc receptor (FcRn) affinity to establish half-life extension technology of therapeutic antibodies
2015 - 2018 Development of analytical method for glycoprotein-glycan interaction by hydrogen/deuterium exchange mass spectrometry

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Papers (96)：

Noritaka Hashii, Yusuke Haruyama, Ryu Hirayama, Ryo Kajita, Yuki Kishino, Toshiki Mochizuki, Kazuko Inoue, Ryoya Goda, Masaki Hoshino, Itsuki Kuroiwa, et al. Versatile intact LC-MS method for evaluating the drug-antibody ratio and drug load distribution of antibody-drug conjugates in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2025. 1258. 124608-124608
Hirotaka Nishimura, Noritaka Hashii, Tomofumi Yamamoto, Yuchen Sun, Takumi Miura, Yoji Sato, Akiko Ishii-Watabe. Usefulness of Size-Exclusion Chromatography-Multi-Angle Light Scattering to Assess Particle Composition and Protein Impurities for Quality Control of Therapeutic Exosome Preparations. Pharmaceutics. 2024. 16. 12. 1526-1526
Rin Miyajima, Hitomi Manaka, Tatsuya Honda, Noritaka Hashii, Masato Suzuki, Masahiro Komeno, Koichi Takao, Akiko Ishii-Watabe, Kazuei Igarashi, Toshihiko Toida, et al. Intracellular polyamine depletion induces N-linked galactosylation of the monoclonal antibody produced by CHO DP-12 cells. Journal of Biotechnology. 2023. 378. 1-10
Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Hiromi Yamamoto, Shuhei Sakakibara, Chikako Ono, Yumi Itoh, Tommy Terooatea, Kazuo Yamashita, Toru Okamoto, et al. Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees. Journal of Experimental Medicine. 2023. 220. 2
SHIBATA Hiroko, KIYOSHI Masato, NAKAKIDO Makoto, ITO Yuji, NISHIKAWA Atsushi, HASHII Noritaka, TADA Minoru, TSUMOTO Kouhei, ISHII-WATABE Akiko. Current situation and issues for stability prediction of biopharmaceuticals. PDA Journal of GMP and Validation in Japan. 2023. 25. 1. 1-9

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MISC (109)：

橋井則貴, 蛭田葉子, 三澤隆史, 大岡伸通, 鈴木琢雄, 出水庸介, 石井明子. Evaluation of peptide-related impurities from nonstandard cyclic peptide by reversed phase chromatography. 日本薬学会年会要旨集(Web). 2024. 144th
大下修一郎, 山代萌, 橋井則貴, LIEW Chia Yen, LIN Yen Ting, NI Chi Kung, 矢木宏和, 蜷川暁, 蜷川暁. 小胞体マンノシダーゼEDEM2-S-S-TXNDC11複合体形成メカニズムの解明. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
伊藤海結, 関根優莉奈, 正田卓司, 橋井則貴, 原園景, 石井明子, 井上英史, 出水庸介, 出水庸介. Development of fluorescent labeling reagents for glycoproteins. 日本薬学会年会要旨集(Web). 2023. 143rd
正田卓司, 橋井則貴, 原園景, 石井明子, 出水庸介. Development of fluorescent labeling reagents for glycoproteins. 日本糖質学会年会要旨集. 2023. 42nd
土屋圭輔, 土屋圭輔, 木吉真人, 橋井則貴, 藤田陽, 藤田陽, 石井明子, 福原潔, 三澤隆史, 出水庸介, et al. Development of helical peptides inhibiting Wnt/β-catenin signaling pathway. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)

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Patents (4)：

Professional career (1)：

薬学博士

Awards (1)：

2007/08 - 第27回日本糖質学会ポスター賞

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