Saito Ryota

Affiliation and department：
Job title： Professor

Research field (3)： Bioorganic chemistry , Chemical biology , Organic functional materials

Research keywords (6)： Biological Inorganic Chemistry , Organic Photochemistry , Organic Synthesis , 生物無機化学 , 有機光化学 , 有機合成化学

Research theme for competitive and other funds (12)：

2019 - 2022 Development of powerful ad exhaustive inhibitors for ribosome-inactivating proteins
2013 - 2016 Development of new types of aldose reductase inhibitors based on the structure of the target enzyme
2003 - 2005 超臨界二酸化炭素の溶媒特性を利用した光不斉反応の制御研究
2003 - 2004 Studies on Novel Syntheses of Fluorecent Tripodal Hexadentate Iigands and Than Application to fluorescent Probes for Microscopic Observation of Cells
2004 - エントロピーの効果が顕著に現れる超臨界流体中での光反応について

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Papers (8)：

Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu and Ryota Saito. Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor. Journal of enzyme inhibition and medicinal chemistry. 2023. 38. 1
Mana Ono, Shouki Abe, Koji Higai, Shoko Higashi, Setsuo Saito, Ryota Saito. An Improved and Practical Synthesis route to Antiproliferative (±)-Shikonin and its O-Acyl Derivatives. Synthetic Communications. 2020. 51. 5. 738-746
Yasuhiro Nishiyama, Masayuki Kaneda, Sadayuki Asaoka, Ryota Saito, Tadashi Mori, Takehiko Wada, Yoshihisa Inoue. Mechanistic study on the enantiodifferentiating anti-Markovnikov photoaddition of alcohols to 1,1-diphenyl-1-alkenes in near-critical and supercritical carbon dioxide. JOURNAL OF PHYSICAL CHEMISTRY A. 2007. 111. 51. 13432-13440
Yamaguchi M, Saito R, Utsumi K, Ochiai A, Kawashima N, Tokuoka Y, Katoh A. The Nicotinic Acid-p-Aminophenylalanine-Hydroxybenzoic Acid Triads Induce apoptosis in Human Leukemia U937 Cells. Heterocycles. 2007. 71. 1503-1508
Yamaguchi M, Saito R, Adachi Y, Yoshikawa Y, Sakurai H, Katoh A. Synthesis of Oxovanadium(IV) and Zinc(II) Complexes of 3-Hydroxy-4-(p-substituted)phenylthiazole-2(3H)- thiones with a S2O2 Coordination Mode and Their Insulin-Mimetic Activities. Heterocycles. 2007. 73. 603-615

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MISC (22)：

Yue Ma, Yuki Wakabayashi, Naruyuki Watatani, Ryota Saito, Takatsugu Hirokawa, Masayuki Tera, Kazuo Nagasawa. Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand. Organic & biomolecular chemistry. 2021. 19. 37. 8035-8040
A Katoh, K Harada, R Saito. Synthesis and characterization of Fe(III) and Pb(II) complexes with 3-hydroxypyridine-2(1H )-thiones. HEMOGLOBIN. 2006. 30. 1. 81-92
A Katoh, M Yamaguchi, R Saito, Y Adachi, H Sakurai. Insulinomimetic vanadyl-hydroxythiazolethione complexes with VO(S2O2) coordination mode: The correlation between the activity and Hammett's substituent constant. CHEMISTRY LETTERS. 2004. 33. 10. 1274-1275
Y Nishiyama, M Kaneda, R Saito, T Mori, T Wada, Y Inoue. Enantiodifferentiating photoaddition of alcohols to 1,1-diphenylpropene in supercritical carbon dioxide: Sudden jump of optical yield at the critical density. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2004. 126. 21. 6568-6569
R Saito, C Inoue, A Katoh. Well-divided and pH-dependent bimodal chemiluminescence of 2-methyl-6-phenyl-8-(4-substituted phenyl)imidazo[1,2-a]pyrazin-3(7H)-ones induced by superoxide anion. HETEROCYCLES. 2004. 63. 4. 759-764

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Patents (1)：

二環性アリール環又はヘテロアリール環を有するピラジン誘導体

Lectures and oral presentations (178)：

GYK(Z)トリペプチドを導入したプテリン-7-カルボキサミドの合成とリシン毒素A鎖阻害活性
(第17回バイオ関連化学シンポジウム 2023)
2 位をアリールスルホニル基及びアリールスルフィニル基で修飾した Botryllazine B 類縁体の合成とアルドース還元酵素阻害活性
(第103日本化学会春季年会 2023)
2位に水素結合性アロイル基を導入した Botryllazine B類の合成とアルドース還元酵素阻害活性
(第103日本化学会春季年会 2023)
4位及び4,5位にアルキル基を有する新規3-ヒドロキシチアゾール-2(3H)チオン類及びそれらの亜鉛錯体の合成とインスリン様活性
(第51回複素環化学討論会 2022)
Botryllazine B誘導体のアルドース還元酵素阻害に関する構造活性相関: 2-ベンゾイル基上の置換基効果
(日本化学会第102春季年会 2022)

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Works (1)：

エントロピー効果が顕著に現れる超臨界流体中での光反応について
2003 -

Education (4)：

- 1998 The University of Electro-Communications
- 1998 The University of Electro-Communications Graduate School, Division of Electro Communications
- 1993 The University of Electro-Communications Faculty of Electro-Communications
- 1993 The University of Electro-Communications Faculty of Electro Communications

Professional career (1)：

Ph D (The University of Electro-Communications)

Work history (15)：

2017/04 - 現在 Toho University Faculty of Science Department of Chemistry Professor
2009/04 - 2017/03 Toho University Faculty of Science Department of Chemistry Associate Professor
2006/04 - 2009/03 Toho University Faculty of Science Department of Chemistry Lecturer
2005/10 - 2006/03 東京農工大学工学部生命工学科助教
2005/10 - 2006/03 東京農工大学工学部生命工学科特任助手

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Committee career (1)：

2017/04 - 現在日本化学会関東支部代表正会員

Association Membership(s) (9)：

アメリカ化学会 , 光化学協会 , 有機合成化学協会 , 日本化学会 , American Chemical Society , Japanese Photochemistry Association , The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , The Japan Society of High Pressure Science and Tecnology

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