Art

J-GLOBAL ID：200902065400477910   Reference number：89A0616085

Synthesis and antimicrobial evaluation of 20-deoxo-20(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives.

20-デオキソ-20-(3,5-ジメチルピペリジン-1-イル)デスマイコシン(チルミコシン,EL-870)と関連環状アミノ誘導体の合成と抗微生物評価

Author (9)： DEBONO M (Eli Lilly and Co., IN, USA) ,  WILLARD K E (Eli Lilly and Co., IN, USA) ,  KIRST H A (Eli Lilly and Co., IN, USA) ,  WIND J A (Eli Lilly and Co., IN, USA) ,  CROUSE G D (Eli Lilly and Co., IN, USA) ,  TAO E V (Eli Lilly and Co., IN, USA) ,  VICENZI J T (Eli Lilly and Co., IN, USA) ,  COUNTER F T (Eli Lilly and Co., IN, USA) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 42  Issue： 8  Page： 1253-1267  Publication year： Aug. 1989 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： macrolide antibiotics ,...
Semi thesaurus term： Pasteurella ,...

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JST classification (3)： Synthesis of antibiotics  (GX04000Z) ,  Structure-activity relationship of drugs  (GV01050B) ,  Eight or more-membered heterocyclic compounds  (CF07120T)

Reference (20)：

• 1) WILSON, R. C.: Chapter 8. Macrolides in veterinary practice. In Macrolide Antibiotics. Chemistry, Biology, and Practice. Ed., S. OMURA, pp. 301 - 347, Academic Press, Inc., 1984
• 2) SAKAKIBARA, H. & S. OMURA: Chapter 3. Chemical modification and structure - activity relationship of macrolides. In Macrolide Antibiotics. Chemistry, Biology, and Practice. Ed., S. OMURA, pp. 85 - 125, Academic Press, Inc., 1984
• 3) HAMILL, R. L. & W. M. STARK: Macrocin, a new antibiotic, and lactenocin, an active degradation product. J. Antibiotics, Ser. A 17: 133-139, 1964
• 4) HAMILL, R. L.; M. E. HANEY, Jr., M. STAMPER & P. F. WILEY: Tylosin, a new antibiotic. II. Isolation, properties and preparation of desmycosin, a microbiologically active degradation product. Antibiot. Chemother. 11: 328-334, 1961
• 5) DEBONO, M.; K. E. WILLARD, H. A. KIRST, G. D. CROUSE & E. E. OSE: Synthesis and structure-activity studies of 20-deoxo-20-substituted amino-rnacrolide antibiotics. Program and Abstracts of the 25th Intersci. Conf. on Antimicrob. Agents Chemother., No. 1145, p. 302, Minneapolis, Sept. 29-Oct. 2, 1985

Terms in the title (7)： デスマイコシン ,  チルミコシン ,  EL-870 ,  環状 ,  誘導体 ,  微生物 ,  評価