Art

J-GLOBAL ID：200902075885677101   Reference number：91A0219339

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.

ラクタシスチン,神経芽細胞腫細胞の軸索形成を誘発する新規微生物代謝産物

Author (7)： OMURA S (Kitasato Univ., Tokyo, JPN) ,  FUJIMOTO T (Kitasato Univ., Tokyo, JPN) ,  OTOGURO K (Kitasato Univ., Tokyo, JPN) ,  MATSUZAKI K (Kitasato Univ., Tokyo, JPN) ,  MORIGUCHI R (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  SASAKI Y (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 44  Issue： 1  Page： 113-116  Publication year： Jan. 1991 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： bioactive factor ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (2)： Biological function  (EB02020R) ,  Drugs acting on nervous system in general  (GW02000I)

Substance index (1)： Lactacystin

Reference (14)：

• 1) PEREZ-POLO, J. R.: Neuronotrophic factors. In Cell Culture in Neurosciences. Eds., J. E. BOTTENSTEIN & G. SATO, pp. 95-123, Plenum Press, 1985
• 2) HEFTI, F. & W. J. WEINER: Nerve growth factor and Alzheimer's disease. Ann. Neuro. 20: 275-281, 1986
• 3) BARDE, Y.-A.: Trophic factors and neuronal survival. Neuron 2: 1525-1534, 1989
• 4) OMURA, S.; K. MATSUZAKI, T. FUJIMOTO, K. KOSUGE, T. FURUYA, S. FUJITA & A. NAKAGAWA: Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells. J. Antibiotics 44: 117-118, 1991
• 5) WAYMIRE, J. C.; K. N. GILMER-WAYMIRE & R. E. BOEHME: Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells. J. Neurochem. 31: 699-706, 1978

Terms in the title (5)： ラクタシスチン ,  神経芽細胞腫細胞 ,  軸索形成 ,  誘発 ,  微生物代謝産物