Frequent Epigenetic Silencing of the p16 Gene in Non-small Cell Lung Cancers of Tobacco Smokers.

YANAGAWA N; TAMURA G; OIZUMI H; TAKAHASHI N; SHIMAZAKI Y; MOTOYAMA T

Art

J-GLOBAL ID：200902100600176303 Reference number：02A0858186

Frequent Epigenetic Silencing of the p16 Gene in Non-small Cell Lung Cancers of Tobacco Smokers.

喫煙者における非小細胞肺癌のp16遺伝子に頻発する後成的サイレンシング

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Material：
Volume： 93 Issue： 10 Page： 1107-1113 Publication year： Oct. 31, 2002
JST Material Number： F0633A ISSN： 0910-5050 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Chemistry,biochemistry and pathology of tumors(=neoplasms) , Tumors(=neoplasms)of respiratory system , Tobacco(=cigarette)

Reference (37)：

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BELINSKY, S. A. Aberrant methylation of p16^<INK4A> is an early event in lung cancer and a potential marker for early diagnosis. Proc. Natl. Acad. Sci. USA. 1998, 95, 11891-11896
KIM, D. H. p16^<INK4a> and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res. 2001, 61, 3419-3424
GREENBLATT, M. S. Mutations in the p53 tumor suppressor gene : clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994, 54, 4855-4878
DENISSENKO, M. F. Preferential formation of benzo[a] pyrene adducts at lung cancer mutational hotspots in p53. Science. 1996, 274, 430-432

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