Art

J-GLOBAL ID：200902106120772109   Reference number：01A0226454

A Prodrug of NMDA/Glycine Site Antagonist, L-703,717, with Improved BBB Permeability. 4-Acetoxy Derivative and Its Positron-Emitter Labeled Analog.

BBB透過性が改善された,NMDA/グリシン部位きっ抗薬,L-703717のプロドラッグ 4-アセトキシ誘導体及び陽電子放出体標識類似体

Author (9)： HARADAHIRA T (National Inst. Rediological Sci., Chiba, JPN) ,  ZHANG M-R (SHI Accelerator Serv., Tokyo, JPN) ,  MAEDA J (SHI Accelerator Serv., Tokyo, JPN) ,  OKAUCHI T (SHI Accelerator Serv., Tokyo, JPN) ,  KIDA T (SHI Accelerator Serv., Tokyo, JPN) ,  KAWABE K (Japan Sci. and Technol. Corp., Saitama, JPN) ,  SASAKI S (Kyushu Univ., Fukuoka, JPN) ,  SUHARA T (National Inst. Rediological Sci., Chiba, JPN) ,  SUZUKI K (National Inst. Rediological Sci., Chiba, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 49  Issue： 2  Page： 147-150  Publication year： Feb. 01, 2001 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...

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JST classification (2)： Quinolines,isoquinolines  (CF07096H) ,  Synthesis of drugs  (GV01030F)

Substance index (6)： L-701324 ,  L-703717 ,  3-[3-(4-Methoxybenzyl)phenyl]-4-acetoxy-7-chloro-1,2-dihydroquinoline-2-one ,  3-[3-(4-Hydroxybenzyl)phenyl]-4-hydroxy-7-chloro-1,2-dihydroquinoline-2-one ,  [¹¹C]L-703717 ,  Acetyl-[¹¹C]L-703717

Reference (10)：

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Terms in the title (9)： 透過性 ,  NMDA ,  グリシン ,  きっ抗薬 ,  L-703717 ,  プロドラッグ ,  誘導体 ,  標識 ,  類似体