Art

J-GLOBAL ID：200902107335611803   Reference number：97A0202902

Synthetic approaches toward ecteinascidins. Part 1. Preparation of an (E)-2-arylidene-3-benzyl-1,5-imino-3-benzazocin-4-one having a protected phenol in the E-ring.

エクテイナシジンの合成法 1 E環に保護フェノール基をもつ(E)-2-アリーリデン-3-ベンジル-1,5-イミノ-3-ベンゾアゾシン-4-オンの調製

Author (5)： SAITO N (Meiji Coll. Pharmacy, Tokyo, JPN) ,  TASHIRO K (Meiji Coll. Pharmacy, Tokyo, JPN) ,  MARU Y (Meiji Coll. Pharmacy, Tokyo, JPN) ,  YAMAGUCHI K (Chiba Univ., Chiba, JPN) ,  KUBO A (Meiji Coll. Pharmacy, Tokyo, JPN)
Material： Journal of the Chemical Society. Perkin Transactions. 1  (Perkin Transactions 1)
Issue： 1  Page： 53-69  Publication year： Jan. 07, 1997 
JST Material Number： A0499B  ISSN： 1472-7781  CODEN： JCPRB4  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： bridged compound ,...

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JST classification (3)： Pyrazines  (CF07104N) ,  Alkaloids  (CF10030D) ,  Synthesis of drugs  (GV01030F)

Substance index (13)： (2E)-2-[(6-Methoxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-7,9,10-trimethoxy-8,11-dimethyl-2,3,5,6-tetrahydro-1β,5β-epimino-3-benzazocin-4(1H)-one ,  (2E)-2-[(6-Benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-7,9,10-trimethoxy-8,11-dimethyl-2,3,5,6-tetrahydro-1β,5β-epimino-3-benzazocin-4(1H)-one ,  (2E)-2-[(6-Benzyloxy-1,3-benzodioxol-5-yl)methylene]-3-benzyl-9-methoxy-8,11-dimethyl-2,3,5,6-tetrahydro-1β,5β-epimino-3-benzazocin-4(1H)-one ,  (2E)-2-[(6-Benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-9-methoxy-8,11-dimethyl-2,3,5,6-tetrahydro-1β,5β-epimino-3-benzazocin-4(1H)-one ,  (5Z)-2-(2,4,5-Trimethoxy-3-methylbenzyl)-3-oxo-4-benzyl-5-[(6-methoxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-6-hydroxy-1-piperazinecarboxylic acid isopropyl ester ,  (5Z)-2-(2,4,5-Trimethoxy-3-methylbenzyl)-3-oxo-4-benzyl-5-[(6-benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-6-hydroxy-1-piperazinecarboxylic acid isopropyl ester ,  (5Z)-2-(3-Methyl-4-methoxybenzyl)-3-oxo-4-benzyl-5-[(6-benzyloxy-1,3-benzodioxol-5-yl)methylene]-6-hydroxy-1-piperazinecarboxylic acid isopropyl ester ,  (5Z)-2-(3-Methyl-4-methoxybenzyl)-3-oxo-4-benzyl-5-[(6-benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-6-hydroxy-1-piperazinecarboxylic acid isopropyl ester ,  (2E)-2-[(6-Methoxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-4-oxo-7,9,10-trimethoxy-8-methyl-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  (2E)-2-[(6-Benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-4-oxo-7,9,10-trimethoxy-8-methyl-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  (2E)-2-[(6-Benzyloxy-1,3-benzodioxol-5-yl)methylene]-3-benzyl-4-oxo-8-methyl-9-methoxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  (2E)-2-[(6-Benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-4-oxo-8-methyl-9-methoxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  4-Methyl-7β-(2,4,5-trimethoxy-3-methylbenzyl)-8-oxo-9-benzyl-8,9-dihydro-5aαH-1,3,5-trioxa-6,9-diaza-2H-cyclopent[b]anthracene-6(7H)-carboxylic acid isopropyl ester

Terms in the title (5)： 合成法 ,  環 ,  フェノール基 ,  ベンジル ,  調製