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J-GLOBAL ID：200902110994376669   Reference number：99A0391600

Enhancement of the Anti-tumor Effect of 5′-Deoxy-5-fluorouridine by Transfection of Thymidine Phosphorylase Gene into Human Colon Cancer Cells.

ヒト結腸癌細胞へのチミジンホスホリラーゼ遺伝子導入による5’-デオキシ-5-フルオロウラシルの抗癌効果の増強

Author (9)： KANYAMA H (Osaka Univ. Medical School, Osaka) ,  TOMITA N (Osaka Univ. Medical School, Osaka) ,  YAMANO T (Osaka Univ. Medical School, Osaka) ,  MIYOSHI Y (Osaka Univ. Medical School, Osaka) ,  OHUE M (Osaka Univ. Medical School, Osaka) ,  FUJIWARA Y (Osaka Univ. Medical School, Osaka) ,  SEKIMOTO M (Osaka Univ. Medical School, Osaka) ,  SAKITA I (Osaka Univ. Medical School, Osaka) ,  MONDEN M (Osaka Univ. Medical School, Osaka)
Material： Japanese Journal of Cancer Research  (Proceedings. Annual Meeting of the Japanese Cancer Association)
Volume： 90  Issue： 4  Page： 454-459  Publication year： Apr. 30, 1999 
JST Material Number： F0633A  ISSN： 0910-5050  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： バイスタンダー効果

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Fluorouracil ,  5'-DFUR

Reference (25)：

• MULLEN, C. A. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc. Natl. Acad. Sci. USA. 1992, 89, 33-37
• MULLEN, C. A. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. Cancer Res. 1994, 54, 1503-1506
• SUGAYA, S. Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complex. Hum. Gene. Ther. 1996, 7, 223-230
• BODYCOTE, J. Metabolic breakdown of [^3H]thymidine and the inability to measure human lymphocyte proliferation by incorporation of radioactivity. Proc. Natl. Acad. Sci. USA. 1986, 83, 4749-4753
• BIRINE, G. D. Studies of fluorinated pyrimidines. XVIII. The degradation of 5-fluoro-2-deoxyuridine and related compounds by nucleoside phosphorylase. Biochemistry. 1963, 2, 566-572

Terms in the title (8)： ヒト ,  結腸癌 ,  細胞 ,  チミジンホスホリラーゼ ,  遺伝子導入 ,  5-フルオロウラシル ,  抗癌効果 ,  増強