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J-GLOBAL ID：200902112402073998   Reference number：00A0416694

Ser787 in the Proline-Rich Region of Human MAP4 is a Critical Phosphorylation Site that Reduces its Activity to Promote Tubulin Polymerization.

ヒトMAP4の高プロリン領域のSer787はその活性を低下させチューブリン重合を促進する決定的りん酸化部位である

Author (9)： KITAGAWA H (Tokyo Metropolitan Univ., Tokyo, JPN) ,  IIDA J (Tokyo Metropolitan Univ., Tokyo, JPN) ,  UCHIDA A (Tokyo Metropolitan Univ., Tokyo, JPN) ,  HOTANI H (Nagoya Univ., Nagoya, JPN) ,  OOKATA K (Tokyo Inst. Technol., Yokohama, JPN) ,  MUROFUSHI H (Univ. Tokyo, Tokyo, JPN) ,  BULINSKI J C (Columbia Univ., New York) ,  KISHIMOTO T (Tokyo Inst. Technol., Yokohama, JPN) ,  HISANAGA S (Tokyo Metropolitan Univ., Tokyo, JPN)
Material： Cell Structure and Function  (Cell Struct Funct)
Volume： 25  Issue： 1  Page： 33-39  Publication year： Feb. 2000 
JST Material Number： Y0044A  ISSN： 0386-7196  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： cdc2 kinase

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JST classification (2)： Biological function  (EB03040U) ,  Cell components in general  (EF03010Z)

Reference (36)：

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• AIZAWA, H. Functional analyses of the domain structure of microtubule-associated protein-4(MAP-U). J. Biol. Chem. 1991, 266, 9841-9846
• AIZAWA, H. Microtubule destabilization by cdc2/H1 histone kinase: phosphorylation of a "Pro-rich region" in the microtubule-binding domain of MAP4. Biochem. Biophys. Res. Commun. 1991, 179, 1620-1626
• ANDERSEN, S. S. L. Effect on microtubule dynamics of XMAP230, a microtubule-associated protein present in Xenopus laevis eggs and dividing cells. J. Biol. Chem. 1994, 127, 1289-1299
• BELMONT, L. D. Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell. 1990, 62, 579-589

Terms in the title (8)： ヒト ,  MAP4 ,  プロリン ,  活性 ,  チューブリン ,  重合 ,  促進 ,  りん酸化部位