Art

J-GLOBAL ID：200902129358753560   Reference number：93A0368908

Neurotropic Pyrimidine Heterocyclic Compounds. I. The Newly Synthesized Pyrimidine Compounds Promote Neurite Outgrowth of GOTO and Neuro 2a Neuroblastoma Cell Lines, and Potentiate Nerve Growth Factor (NGF)-Induced Neurite Sprouting of PC 12 Cells.

向神経性ピリミジン複素環式化合物 1 新合成ピリミジン化合物はGOTOとニューロ2a神経芽細胞腫細胞株の軸索伸展を増進し,PC12細胞の神経成長因子(NGF)誘発軸索出芽を促進する

Author (9)： AWAYA A (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  KOBAYASHI H (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  HORIKOMI K (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  TANAKA S (Saga Medical School, Saga, JPN) ,  KABIR A M (National Center of Neurology and Psychiatry, Tokyo, JPN) ,  YOKOYAMA K (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  OHNO H (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  KATO K (Mitsui Pharmaceuticals, Inc., Tokyo, JPN) ,  NAKAMURA S (National Center of Neurology and Psychiatry, Tokyo, JPN)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 16  Issue： 3  Page： 248-253  Publication year： Mar. 1993 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： neuroblastoma ,...

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JST classification (1)： Drugs acting on nervous system in general  (GW02000I)

Substance index (8)： 2-Piperazino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one ,  6-Methyl-2-piperazino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one ,  6-Ethyl-2-piperazino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one ,  7-Methyl-2-piperazino-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one ,  2-Methyl-6-piperazino-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one ,  6-Methyl-2-piperazinopyrido[4,3-d]pyrimidin-5(6H)-one ,  6-Ethyl-2-piperazinopyrido[4,3-d]pyrimidin-5(6H)-one ,  Isaxonine

Reference (19)：

• 1) S. Tsuji, M. Arita and Y. Nagai, J. Biochem., (Tokyo), 94, 303 (1983).
• 2) M. Arita, S. Tsuji, M. Omatsu and Y. Nagai, J. Neurosci. Res., 12, 289 (1984).
• 3) J. Nakajima, S. Tsuji and Y. Nagai, Biochem. Biophys. Acta, 876, 65 (1986).
• 5) H. Nishino, H. Ochiai, Y. Momose, A. Awaya and T. Ono, Neuroscience, 22, S684 (1987).
• 6) H. Nishino, T. Hashitani, Y. Isobe, F. Furuyama, H. Sato, M. Kumazaki, K. Horikomi and A. Awaya, Brain Res., 534,73 (1990).

Terms in the title (14)： 神経 ,  ピリミジン ,  複素環式化合物 ,  ピリミジン化合物 ,  神経芽細胞腫 ,  細胞株 ,  軸索 ,  伸展 ,  PC12細胞 ,  神経成長因子 ,  NGF ,  誘発 ,  出芽 ,  促進