Art

J-GLOBAL ID：200902130899766787   Reference number：02A0948700

Cloned Cytosine Deaminase Gene Expression of Bifidobacterium longum and Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors.

Bifidobacterium longumのクローン化シトシンデアミナーゼ遺伝子の発現および低酸素固形腫ようの酵素/プロドラッグ治療法への応用

Author (7)： NAKAMURA T (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  SASAKI T (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  FUJIMORI M (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  YAZAWA K (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  KANO Y (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  AMANO J (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  TANIGUCHI S (Shinshu Univ. School of Medicine, Matsumoto, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 66  Issue： 11  Page： 2362-2366  Publication year： Nov. 23, 2002 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *hydrolyase ,...
Semi thesaurus term： Bifidobacterium ,...

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JST classification (2)： Enzyme physiology  (EG03052C) ,  Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y)

Substance index (2)： Fluorouracil ,  Flucytosine

Reference (19)：

• 1) Brown, J. M., The hypoxic cell: a target for selective cancer therapy. Cancer Res., 59, 5863-5870 (1999).
• 2) Vaupel, P. W., In “Oxygenation of solid tumors in drug resistance in oncology”, ed. Teicher, B. A., Marcel Dekker, New York, pp. 53-85 (1993).
• 3) Kimura, N. T., Taniguchi, S., Aoki, K., and Baba, T., Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res., 40, 2061-2068 (1980).
• 4) Fox, M. E., Lemmon, M. J., Mauchline, M. L., Davis, T. O., Giaccia, A. J., Minton, N. P., and Brown, J. M., Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Gene Ther., 3, 173-178 (1996).
• 5) Theys, J., Landuyt, W., Nuyts, S., Van Mellaert, L., van Oosterom, A., Lambin, P., and Anne, J., Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther., 8, 294-297 (2001).

Terms in the title (10)： Bifidobacterium ,  シトシンデアミナーゼ ,  遺伝子 ,  発現 ,  低酸素 ,  固形腫よう ,  酵素 ,  プロドラッグ ,  治療法 ,  応用