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J-GLOBAL ID：200902133370865045   Reference number：01A0721275

UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. VI(1). Structure-Activity Relationships of UK-2A.

UK-2A,B,CとD,Streptomycessp.517-02から得た新規の抗真菌性抗生物質 VI(1) UK-2Aの構造活性相関

Author (4)： USUKI Y (Osaka City Univ., Osaka, JPN) ,  TANI K (Osaka City Univ., Osaka, JPN) ,  FUJITA K (Osaka City Univ., Osaka, JPN) ,  TANIGUCHI M (Osaka City Univ., Osaka, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 7  Page： 600-602  Publication year： Jul. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antibiotics ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (2)： Pharmacology of antibiotics in general  (GX05010R) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (19)： Antimycin A3 ,  UK-2A ,  UK-2B ,  UK-2C ,  UK-2D ,  N-Hexadecyl-3-hydroxy-4-methoxypyridine-2-carboxamide ,  N-Dodecyl-3-hydroxy-4-methoxypyridine-2-carboxamide ,  C8-UK-2A ,  N-Butyl-3-hydroxy-4-methoxypyridine-2-carboxamide ,  N-(3,6,9-Trimethyl-2,5,8-decatrienyl)-3-hydroxy-4-methoxypyridine-2-carboxamide ,  N-(3,6-Dimethyl-2,5-heptadienyl)-3-hydroxy-4-methoxypyridine-2-carboxamide ,  N-(3-Methyl-2-butenyl)-3-hydroxy-4-methoxypyridine-2-carboxamide ,  N-Octyl-2-hydroxy-3-methoxybenzamide ,  N-Octyl-3-hydroxypyridine-2-carboxamide ,  N-Octyl-2-hydroxypyridine-3-carboxamide ,  N-Hexadecyl-2-hydroxy-3-(formylamino)benzamide ,  N-Dodecyl-2-hydroxy-3-(formylamino)benzamide ,  3-(Formylamino)-N-octylsalicylic amide ,  N-Butyl-2-hydroxy-3-(formylamino)benzamide

Reference (11)：

• 1) UEKI, M.; K. ABE, M, HANAFI, K. SHIBATA, T. TANAKA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation and biological properties. J. Antibiotics 49: 1226-1231, 1996
• 2) HANAFI, M.; K. SHIBATA, M. UEKI & M. TANIGUCHI: UK2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation. J. Antibiotics 49: 1226-1231, 1996
• 3) UEKI, M. & M. TANIGUCHI: The mode of action of UK2A and UK-3A, Cnovel antifungal antibiotics from Streptomyces sp. 517-02. J. Antibiotics 50: 1052-1057, 1997
• 4) SHIBATA, K.; M. HANAFI, J. FUJII, O. SAKANAKA, K. IINUMA, M. UEKI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. III. Absolute configuration of an antifungal antibiotic, UK-2A and consideration of its conformation. J. Antibiotics 51: 1113-1116, 1998
• 5) TAKIMOTO, H.; K. MACHIDA, M. UEKI, T. TANAKA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. IV Comparative studies of UK-2A with antimycin A₃ on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J. Antibiotics 52: 480-484, 1999

Terms in the title (3)： UK-2A ,  抗真菌性抗生物質 ,  構造活性相関