Art

J-GLOBAL ID：200902133378137553   Reference number：00A0495315

Advantage of Recombinant Technology for the Identification of Cardiac Myosin Epitope of Severe Autoimmune Myocarditis in Lewis Rats.

ルイスラットにおける重症自己免疫性心筋炎の心臓ミオシンエピトープ同定のための遺伝子組換技術の利点

Author (4)： KOHNO K (Kitasato Univ. School of Medicine, Kanagawa, JPN) ,  TAKAGAKI Y (Kitasato Univ. School of Medicine, Kanagawa, JPN) ,  NAKAJIMA Y (Kitasato Univ. School of Medicine, Kanagawa, JPN) ,  IZUMI T (Kitasato Univ. School of Medicine, Kanagawa, JPN)
Material： Japanese Heart Journal  (Jpn Heart J)
Volume： 41  Issue： 1  Page： 67-77  Publication year： Jan. 2000 
JST Material Number： Z0752A  ISSN： 0021-4868  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *gene manipulation ,...
Semi thesaurus term： recombination

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JST classification (3)： Gene manipulation  (EC02050B) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Antigens,antibodies,complements in general  (ED04010A)

Reference (12)：

• 1) Neu N, Rose NR, Bisel KW, Herskowitz A, Gurri-Glass G, Craig SW. Cardiac myosin induced myocarditis in genetically predisposed mice. J Immunol 1987; 139: 3630-36.
• 2) Pummerer CL, Luze K, Grassl G, et al. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J Clin Invest 1996; 97: 2057-62.
• 3) Donermeyer DL, Beisel KW, Allen PM, Smith SC. Myocarditis-inducing epitope of myosin binds constitutively and stably to I-Ak on antigen-presenting cells in the heart. J Exp Med 1995; 182: 1291-300.
• 4) Bachmaier K, Neu N, Yeung RS, Mak TW, Liu P, Penninger JM. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation 1999; 99: 1885-91.
• 5) Wegmann KW, Zhao W, Griffin AC, Hickey WF. Identification of myocardiogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides. J Immunol 1994; 153: 892-900.

Terms in the title (8)： ラット ,  重症 ,  自己免疫性心筋炎 ,  心臓ミオシン ,  エピトープ ,  同定 ,  遺伝子組換 ,  利点