Art

J-GLOBAL ID：200902134214656807   Reference number：96A1032038

Madindoline, a Novel Inhibitor of IL-6 Activity from Streptomyces sp. K93-0711. I. Taxonomy, Fermentation, Isolation and Biological Activities.

マジンドリン,Streptomyces sp.K93-0711からの新規IL-6活性抑制剤 1 分類,発酵,単離と生物活性

Author (9)： HAYASHI M (Kitasato Univ., Tokyo, JPN) ,  KIM Y-P (Kitasato Univ., Tokyo, JPN) ,  TAKAMATSU S (Kitasato Univ., Tokyo, JPN) ,  ENOMOTO A (Kitasato Univ., Tokyo, JPN) ,  SHINOSE M (Kitasato Univ., Tokyo, JPN) ,  TAKAHASHI Y (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  KOMIYAMA K (Kitasato Univ., Tokyo, JPN) ,  OHMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 49  Issue： 11  Page： 1091-1095  Publication year： Nov. 1996 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotics fermentation ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (1)： (+)-Madindoline A

Reference (17)：

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• 2) OPPENHEIM, J. J.; C. O. C. ZAGEARISE, N. MUKAIDA & K. MATSUSHIMA: Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol. 9: 617-648, 1991
• 3) KISHIMOTO, T.; S. AKIRA & T. TAGA: IL-6 receptor and mechanism of signal transduction. Int. J. Immunopharmacol. 14: 431-438, 1992
• 4) HIRANO, T.: Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias. Int. J. Cell Cloning 9: 166-184, 1991
• 5) HOCKE, G. M.; D. BARRY & G. H. FEY: Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene. Mol. Cell Biol. 12: 2282-2294, 1992

Terms in the title (9)： マジンドリン ,  Streptomyces ,  IL-6 ,  活性 ,  抑制剤 ,  分類 ,  発酵 ,  単離 ,  生物活性