Art

J-GLOBAL ID：200902141139384878   Reference number：98A0544180

Cytotoxic Actions of FTY720, a Novel Immunosuppressant, on Thymocytes and Brain Neurons Dissociated From the Rat.

ラットから採取した胸腺細胞と脳神経細胞に及ぼす新規免疫抑制薬FTY720の細胞障害性作用

Author (8)： OYAMA Y (Univ. Tokushima, Tokushima, JPN) ,  CHIKAHISA L (Univ. Tokushima, Tokushima, JPN) ,  KANEMARU K (Univ. Tokushima, Tokushima, JPN) ,  NAKATA M (Univ. Tokushima, Tokushima, JPN) ,  NOGUCHI S (Univ. Tokushima, Tokushima, JPN) ,  NAGANO T (Univ. Tokushima, Tokushima, JPN) ,  OKAZAKI E (Univ. Tokushima, Tokushima, JPN) ,  HIRATA A (Univ. Tokushima, Tokushima, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 76  Issue： 4  Page： 377-385  Publication year： Apr. 1998 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： *T lymphocyte ,...

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JST classification (1)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Fingolimod Hydrochloride

Reference (22)：

• 1 Adachi K, Kohara T, Nakano N, Arita M, Chiba K, Mishina T, Sasaki S and Fujita T: Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem 5, 853 – 856 (1995)
• 2 Fujita T, Yoneta M, Hirose R, Sasaki S, Inoue K, Kiuchi M, Hirase S, Adachi K, Arita M and Chiba K: Simple compounds, 2-alkyl-2-amino-1,3-propanediols, have potent immunosuppressive activity. Bioorg Med Chem 5, 847 – 852 (1995)
• 3 Suzuki S, Enosawa S, Kakefuda T, Shinomiya T, Amari M, Naoe S, Hoshino Y and Chiba K: A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantaion. Transplantation 61, 200 – 205 (1996)
• 4 Oyama Y, Chikahisa L, Ueha T, Hatakeyama Y and Kokubun T: Changes in membrane permeability induced by amyloid β-protein fragment 25 – 35 in brain neurons dissociated from rats. Jpn J Pharmacol 68, 77 – 83 (1995)
• 5 Okazaki E, Chikahisa L, Kanemaru K and Oyama Y: Flow cytometric analysis of the H₂O₂-induced increase in intracellular Ca²⁺ concentration of rat thymocytes. Jpn J Pharmacol 71, 273 – 280 (1996)

Terms in the title (8)： ラット ,  採取 ,  胸腺細胞 ,  脳神経 ,  細胞 ,  免疫抑制薬 ,  FTY720 ,  細胞障害性