Art

J-GLOBAL ID：200902141520794713   Reference number：02A0590797

Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: Optimization of assay conditions.

C末端21アミノ酸欠失したNS5b蛋白質を用いたHCV RdRpの測定 分析条件の最適化

Author (8)： UCHIYAMA Y (Univ. Tokyo, Tokyo, JPN) ,  HUANG Y (Univ. Tokyo, Tokyo, JPN) ,  KANAMORI H (Univ. Tokyo, Tokyo, JPN) ,  UCHIDA M (Osaka Univ., Osaka, JPN) ,  DOI T (Osaka Univ., Osaka, JPN) ,  TAKAMIZAWA A (Res. Foundation for Microbial Disease of Osaka Univ., Kagawa, JPN) ,  HAMAKUBO T (Univ. Tokyo, Tokyo, JPN) ,  KODAMA T (Univ. Tokyo, Tokyo, JPN)
Material： Hepatology Research  (Hepatol Res)
Volume： 23  Issue： 2  Page： 90-97  Publication year： Jun. 2002 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *hepatitis C virus ,...
Semi thesaurus term： NS5b蛋白質

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JST classification (2)： Virus biochemistry  (EG04030F) ,  Biochemical analytical methods  (EA03030G)

Reference (21)：

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• KUO, G. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989, 244, 362-364
• TAKAMIZAWA, A. Structure and organization of the hepatitis C virus genome isolated from human carries. J Virol. 1991, 65, 1105-1113
• ECKART, MR. The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem Biophys Res Commun. 1993, 192, 399-406
• LIN, C. Processing in the hepatitis C virus E2-NS2 region : identification of p7 and two distinct E2-sepecific products with different C termini. J Virol. 1994, 68, 5063-5073

Terms in the title (7)： C末端 ,  アミノ酸 ,  欠失 ,  NS5B蛋白質 ,  HCV ,  分析 ,  最適化