Art

J-GLOBAL ID：200902153165611996   Reference number：94A0095720

Isochromophilones I and II, novel inhibitors against gp120-CD4 binding from Penicillium sp.

イソクロモフィロンI及びII,Penicillium sp.が生産する物質で,gp120-CD4結合に対する新規の阻害剤

Author (5)： OMURA S (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  MATSUZAKI K (Kitasato Univ., Tokyo, JPN) ,  IKEDA H (Kitasato Univ., Tokyo, JPN) ,  MASUMA R (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 46  Issue： 12  Page： 1908-1911  Publication year： Dec. 1993 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotics ,...
Semi thesaurus term： Penicillium ,...

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JST classification (1)： Pharmacology of antibiotics in general  (GX05010R)

Substance index (5)： Isochromophilone Ia ,  Isochromophilone Ib ,  Isochromophilone IIa ,  Isochromoplilone IIb ,  Sclerotiorin

Reference (7)：

• 1) MCDOUGOL, J. S.; M. S. KENNEDY, J. M. SLIGH, S. P. CORT, A. MAWLE & J. K. A. NICHOLSON: Binding of HTLV-III/LAV to T4⁺ cells by a complex of the 110K viral protein and the T4 molecule. Science 231: 382-385, 1986
• 2) SADROSKI, J.; W. C. GOH, C. ROSEN, K. CAMPBELL & W. A. HASELTIME: Role of HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature 322: 470-474, 1986
• 3) LIFSON, J. D.; M. B. FEINBERG, G. R. REYES, L. RABIN, B. BANAPOUR, S. CHAKRABARTI, B. Moss, F. WONG-STAAL, K. S. STEIMER & E. G. ENGLEMAN: Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 323: 725-728, 1986
• 4) JOHNSTON, M. I. & D. F. HOTH: Present status and future prospects for HIV therapies. Science 260: 1286-1293,1993
• 5) GILBERT, M.; J. KIRIHARA & J. MILLS: Enzyme-linked immunoassay for human immunodeficiency virus type 1 envelope glycoprotein 120. J. Clin. Microbiol. 29: 142-147, 1991

Terms in the title (5)： Penicillium ,  物質 ,  gp120 ,  CD4 ,  阻害剤