Art

J-GLOBAL ID：200902156562042140   Reference number：99A0366862

Optically Active Antifungal Azoles. IX. An Alternative Synthetic Route for 2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone and Its Analogs.

光学活性抗真菌性アゾール類 IX 2-[(1R,2R)-2-(2,4-ジフルオロフェニル)-2-ヒドロキシ-1-メチル-3-(1H-1,2,4-トリアゾール-1-イル)プロピル]-4-[4-(2,2,3,3-テトラフルオロプロポキシ)フェニル]-3(2H,4H)-1,2,4-トリアゾロン及びその類似体の別の合成経路

Author (5)： KITAZAKI T (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  TASAKA A (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  HOSONO H (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  MATSUSHITA Y (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  ITOH K (Takeda Chemical Ind., Ltd., Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 47  Issue： 3  Page： 360-368  Publication year： Mar. 15, 1999 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=99A0366862&from=J-GLOBAL&jstjournalNo=G0504A") }}

JST classification (2)： Triazoles  (CF07084O) ,  Synthesis of drugs  (GV01030F)

Substance index (12)： TAK-187 ,  1-[(1R)-1-Methyl-2-oxo-2-(2,4-difluorophenyl)ethyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazole-5-one ,  (2S)-Lactic acid benzyl ester ,  L-Lactic acid ethyl ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2-fluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2-fluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]imidazolidine-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]imidazolidine-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2-fluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]imidazolidine-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2-fluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]imidazolidine-2-one

Reference (27)：

• 1) Part VIII: Kitazaki T., Tasaka A., Tamura N., Matsushita Y., Hosono H., Hayashi R., Okonogi K., Itoh K., Chem. Pharm. Bull.
• 2) Kitazaki T., Tamura N., Tasaka A., Matsushita Y., Hayashi R., Okonogi K., Itoh K., Chem. Pharm. Bull., 44, 314-327 (1996).
• 3) a) Tasaka A., Kitazaki T., Tsuchimori N., Matsushita Y., Hayashi R., Okonogi K., Itoh K., Chem. Pharm. Bull., 45, 321-326 (1997)
• b) Itoh K., Okonogi K., Tasaka A., Hayashi R., Tamura N., Tsuchimori N., Kitazaki T., Matsushita Y., Obita J., the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, F74, p. 112 (1996)
• c) Okonogi K., Itoh K., Tasaka A., Kitazaki T., Hayashi R., Obita J., Kitamoto N., Tsuchimori N., the 17th Symposium on Medicinal Chemistry, Tsukuba, 1-P-35, p. 124 (1997).

Terms in the title (8)： 光学活性 ,  抗真菌性 ,  アゾール類 ,  トリアゾール ,  ピル ,  フェニル ,  類似体 ,  合成経路