Art

J-GLOBAL ID：200902157665785260   Reference number：01A0138945

Inhibition of Tumor Cell Growth by A Specific 6-Phosphofructo-2-kinase Inhibitor, N-Bromoacetylethanolamine Phosphate, and Its Analogues.

6-Phosphofructo-2-kinase特異的阻害剤N-ブロモアセチルエタノラミンリン酸およびそのアナログによるガン細胞増殖抑制作用

Author (6)： HIRATA T (Nagasaki Univ., Nagasaki, JPN) ,  WATANABE M (Nagasaki Univ., Nagasaki, JPN) ,  MIURA S (Yamasa Corp., Chiba, JPN) ,  IJICHI K (Yamasa Corp., Chiba, JPN) ,  FUKASAWA M (National Defense Medical Coll., Saitama, JPN) ,  SAKAKIBARA R (Kyushu Women’s Univ., Fukuoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 64  Issue： 10  Page： 2047-2052  Publication year： Oct. 23, 2000 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (14)： Cytarabine ,  N-Bromoacetylethanolamine phosphate ,  N-(2-Methoxyethyl)-2-bromoacetamide ,  N-(2-Ethoxyethyl)-2-bromoacetamide ,  N-(3-Methoxypropyl)-2-bromoacetamide ,  N-(2-Methoxyethyl)-2-chloroacetamide ,  N-(2-Ethoxyethyl)-2-chloroacetamide ,  N-(3-Methoxypropyl)-2-chloroacetamide ,  N-(2-Methoxyethyl)-2-bromopropionamide ,  N-(2-Ethoxyethyl)-2-bromopropionamide ,  N-(3-Methoxypropyl)-2-bromopropionamide ,  2-Chloro-N-(2-hydroxyethyl)acetamide ,  Chloroacetic acid 2-(chloroacetylamino)ethyl ester ,  Fructose 2,6-bisphosphate

Reference (14)：

• 1) Warburg, O., On the origine of cancer cells. Science, 123, 309-314 (1956).
• 2) Uyeda, K., Furuya, E., Richard, C. S., and Yokoyama, M., Fructose-2,6P₂, chemistry and biological function. Mol. Cell. Biochem., 48, 97-120 (1982).
• 3) Uyeda, K. in “CRC Review: A study of enzymes” Vol. II, ed. by S. A. Kuby, CRC Press, Boston, pp. 445-456 (1991).
• 4) Kurland, I. J. and Pilkis, S. J., Covalent control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: insights into autoregulation of a bifunctional enzyme. Protein Sci., 4, 1023-1037 (1995).
• 5) Sakai, A., Kato, M., Fukasawa, M., Ishiguro, M., Furuya, E., and Sakakibara, R. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. J. Biochem., 119, 506-511 (1996).

Terms in the title (5)： 阻害剤 ,  酸 ,  アナログ ,  ガン ,  細胞増殖抑制作用