Microtubule-Stimulated Phosphorylation of tau at Ser202 and Thr205 by cdk5 Decreases Its Microtubule Nucleation Activity.

WADA Y; ISHIGURO K; ITOH T J; UCHIDA T; HOTANI H; SAITO T; KISHIMOTO T; HISANAGA S

Art

J-GLOBAL ID：200902160316153428 Reference number：98A0933215

Microtubule-Stimulated Phosphorylation of tau at Ser202 and Thr205 by cdk5 Decreases Its Microtubule Nucleation Activity.

cdk5による微小管活性化タウのSer202及びThr205位りん酸化はその微小管核形成活性を減少する

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Material：
Volume： 124 Issue： 4 Page： 738-746 Publication year： Oct. 1998
JST Material Number： F0286A ISSN： 0021-924X CODEN： JOBIAO Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Biological function , Enzyme physiology

Reference (49)：

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PAPASOZOMENOS, S. C. Phosphorylation determines two distinct species of tau in the central nervous system. Cell Motil. Cytoskel. 1987, 8, 210-226
HIROKAWA, N. Tau proteins: the molecular structure and mode of binding on microtubules. J. Cell Biol. 1998, 107, 1449-1461
LEE, G. Tau protein: an update on structure and function. Cell Motil. Cytoskel. 1990, 15, 199-203
BRAMBLETT, G. T. Abnormal tau phosphorylation at Ser^<396> in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron. 1993, 10, 1089-1099

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