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J-GLOBAL ID：200902165551652751   Reference number：99A0852861

Treatment With l-cis Diltiazem Before Reperfusion Reduces Infarct Size in the Ischemic Rabbit Heart In Vivo.

In vivo虚血性ウサギ心臓における再潅流前のl-cisジルチアゼム投与は梗塞の病巣を縮小する

Author (4)： NISHIDA M (Univ. Tokyo, Tokyo, JPN) ,  SAKAMOTO K (Univ. Tokyo, Tokyo, JPN) ,  URUSHIDANI T (Univ. Tokyo, Tokyo, JPN) ,  NAGAO T (Univ. Tokyo, Tokyo, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 80  Issue： 4  Page： 319-325  Publication year： Aug. 01, 1999 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *myocardial reperfusion ,...
Semi thesaurus term： *calcium channel blocker ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (2)： l-cis-Diltiazem ,  Diltiazem

Reference (20)：

• 1 Ikeda S, Oka J and Nagao T: Effects of four diltiazem stereoisomers on binding of d-cis-[³H] diltiazem and (+)-[³H] PN200-110 to rabbit T-tubule calcium channels. Eur J Pharmacol 208, 199 - 205 (1991)
• 2 Caretta A, Cavaggioni A and Sorbi RT: Cyclic GMP and the permeability of the disks of the frog photoreceptors. J Physiol (Lond) 295, 171 - 178 (1979)
• 3 Stern JH, Kaupp B and Macleish PR: Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem. Proc Natl Acad Sci USA 83, 1163 - 1167 (1986)
• 4 Quandt FN, Nicol GD and Schnetkamp PPM: Voltage-dependent gating and block of the cyclic-GMP-dependent current in bovine rod outer segments. Neuroscience 42, 629 - 638 (1991)
• 5 Nasa Y, Ichihara K and Abiko Y: Both d-cis and l-cis diltiazem have anti-ischemic action in the isolated, perfused working rat heart. J Pharmacol Exp Ther 255, 680 - 689 (1990)

Terms in the title (10)： 虚血 ,  ウサギ ,  心臓 ,  再潅流 ,  CIS ,  ジルチアゼム ,  投与 ,  梗塞 ,  病巣 ,  縮小