Art

J-GLOBAL ID：200902180038741187   Reference number：01A0078086

Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones.

光学活性抗真菌性アゾール類 X N-[4-(アゾリル)フェニル]-及びN-[4-(アゾリルメチル)フェニル]-N′-[(1R,2R)-2-(2,4-ジフルオロフェニル)-2-ヒドロキシ-1-メチル-3-(1H-1,2,4-トリアゾール-1-イル)プロピル]アゾロン類の合成及び抗真菌活性

Author (8)： KITAZAKI T (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  ICHIKAWA T (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  TASAKA A (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  HOSONO H (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  MATSUSHITA Y (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  HAYASHI R (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  OKONOGI K (Takeda Chemical Ind., Ltd., Osaka, JPN) ,  ITOH K (Takeda Chemical Ind., Ltd., Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 48  Issue： 12  Page： 1935-1946  Publication year： Dec. 01, 2000 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...

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JST classification (2)： Other 5-membered rings with two or more hetero atoms  (CF07085F) ,  Synthesis of drugs  (GV01030F)

Substance index (40)： TAK-187 ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]imidazolidine-2-one ,  2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-4-[4-(1H-tetrazole-1-yl)phenyl]-3,4-dihydro-2H-1,2,4-triazole-3-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2-methyl-4-thiazolyl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2-methyl-4-oxazolyl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2H-1,2,3-triazole-2-ylmethyl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-1,2,3-triazole-1-ylmethyl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-pyrazole-1-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-imidazole-1-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-1,2,4-triazole-1-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2H-1,2,3-triazole-2-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-1,2,3-triazole-1-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(2H-tetrazole-2-yl)phenyl]-4-imidazoline-2-one ,  1-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)propyl]-3-[4-(1H-tetrazole-1-yl)phenyl]-4-imidazoline-2-one ,  TAK-456 ,  1-[(2R,3S)-2-(2,4-Difluorophenyl)-2,3-epoxybutan-1-yl]-1H-1,2,4-triazole ,  4-[4-(2-Methyl-4-thiazolyl)phenyl]-3,4-dihydro-2H-1,2,4-triazole-3-one ,  4-[4-(1H-1,2,4-Triazole-1-yl)phenyl]-3,4-dihydro-2H-1,2,4-triazole-3-one ,  4-[4-(1H-Tetrazole-1-yl)phenyl]-3,4-dihydro-2H-1,2,4-triazole-3-one ,  1-[4-(2-Methyl-4-thiazolyl)phenyl]-4-imidazoline-2-one ,  1-[4-(1H-1,2,4-Triazole-1-yl)phenyl]-4-imidazoline-2-one ,  1-[4-(1H-Tetrazole-1-yl)phenyl]-4-imidazoline-2-one ,  (S)-1-[(R)-2-(2,4-Difluorophenyl)oxiranyl]ethanol ,  1-[(R)-1-[(S)-2-(2,4-Difluorophenyl)oxirane-2β-yl]ethyl]-3-[4-(1H-tetrazole-1-yl)phenyl]-4-imidazoline-2-one ,  (S)-2′,4′-Difluoro-α-hydroxypropiophenone ,  4-Nitrobenzyl chloride ,  1-Fluoro-4-nitrobenzene ,  2-(4-Nitrobenzyl)-2H-1,2,3-triazole ,  2-Methyl-4-(4-nitrophenyl)thiazole ,  2-Methyl-4-(4-nitrophenyl)oxazole ,  4-(2H-1,2,3-Triazole-2-ylmethyl)aniline ,  4-(2-Methyl-4-thiazolyl)aniline ,  4-(2-Methyl-4-oxazolyl)aniline ,  N-[4-(2-Methyl-4-thiazolyl)phenyl]carbamic acid phenyl ester ,  N-[4-(2H-1,2,3-Triazole-2-ylmethyl)phenyl]carbamic acid phenyl ester ,  N-[4-(2-Methyl-4-thiazolyl)phenyl]semicarbazide ,  N-[4-(2H-1,2,3-Triazole-2-ylmethyl)phenyl]semicarbazide ,  N-[4-(2-Methyl-4-thiazolyl)phenyl]-N′-(2,2-diethoxyethyl)urea ,  N-[4-(2H-1,2,3-Triazole-2-ylmethyl)phenyl]-N′-(2,2-diethoxyethyl)urea

Reference (40)：

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Terms in the title (7)： 光学活性 ,  抗真菌性 ,  アゾール類 ,  フェニル ,  トリアゾール ,  ピル ,  抗真菌活性