Art

J-GLOBAL ID：200902190135176660   Reference number：01A0150708

On the role of glutamate within the locus coeruleus during the development of opioid dependence and on the expression of withdrawal from dependence on opioids.

オピオイド身体依存形成および退薬症候発現の脳内機序 青斑核におけるグルタミン酸の役割を中心として

Author (3)： TOKUYAMA SHOGO (昭和大 薬) ,  TAKAHASHI MASAKATSU (長崎大 大学院薬学研究科) ,  YAMAMOTO TOSHINORI (昭和大 薬)
Material： 日本神経精神薬理学雑誌  (Japanese Journal of Neuropsychopharmacology)
Volume： 20  Issue： 4  Page： 141-147  Publication year： Oct. 25, 2000 
JST Material Number： Y0724A  ISSN： 1340-2544  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *opioid peptide ,...
Semi thesaurus term： locus ceruleus ,...

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JST classification (1)： Basic research of addictive analgesics and narcotics  (GW03080Z)

Reference (77)：

• AGHAJANIAN, G. K. Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature. 1978, 276, 186-188
• AGHAJANIAN, G. K. Common alpha 2- and opiate effector mechanisms in the locus coeruleus : Intracellular studies in brain slices. Neuropharmacology. 1987, 26, 793-799
• AGHAJANIAN, G. K. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus : An in vivo microdialysis study. Brain Res. 1994, 636, 126-130
• AKAOKA, H. Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input. J Neurosci. 1991, 11, 3830-3839
• ALREJA, M. Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. J Neurosci. 1993, 13, 3525-3532

Terms in the title (7)： オピオイド ,  身体 ,  退薬症候 ,  発現 ,  青斑核 ,  グルタミン酸 ,  役割