Art

J-GLOBAL ID：200902190252480566   Reference number：97A0127498

Molecular Interaction in Solvents between Pharmaceutical Excipients and Water Insoluble Drug (R)-1-[2,3-Dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea.

製剤添加剤と難溶性薬物(R)-1-[2,3-Dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)ureaとの溶媒中での分子間相互作用

Author (5)： YANG Z (千葉大 薬) ,  YONEMOCHI ETSUO (千葉大 薬) ,  SEKI HIROKO (千葉大 分析セ) ,  YANO KATSUHIKO (山之内製薬 創剤研) ,  YAMAMOTO KEIJI (千葉大 薬)
Material： 薬剤学  (Journal of Pharmaceutical Science and Technology, Japan)
Volume： 56  Issue： 4  Page： 224-231  Publication year： Dec. 1996 
JST Material Number： G0234A  ISSN： 0372-7629  CODEN： YAKUA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： drug for peptic ulcer ,...
Semi thesaurus term： pharmaceutic aid ,...

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JST classification (3)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Solid preparations  (GY02030V) ,  Basic biopharmacy  (GY01021U)

Substance index (1)： YM-022

Reference (17)：

• SATOH, M. New 1, 4-benzodiazepin-2-one derivatives as gastrin/cholecystokinin-B antagonists. Chem. Pharm. Bull. 1995, 43, 2159-2167
• NISHIDA, A. Pharmacological profile of (R)-1-[2, 3-dihydro-1-(O-methylphenacyl)-2-oxo-5-phenyl-1H-1, 4-benzodiazepin-3-yl]-3-(m-tolyl) urea (YM022), a new potent and selective gastrin/cholecystokinin (CCK)-B receptor antagonist, in vitro and in vivo. J. Pharmacol. Exp. Ther. 1994, 169, 725-731
• NISHIDA, A. YM022 {(R)-1-[2, 3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1, 4-benzodiazepin-3-yl]-3-(3-methylphenyl) urea}, a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats. J. Pharmacol. Exp. Ther. 1994, 270, 1256-1261
• 梶山篤司. 難溶性薬物の固体分散体化による消化管吸収性改善. 日本薬学会第116年会講演要旨集, 金沢. 1996, 4, 19
• 矢野克彦. 難溶性薬物 (R)-1-[2, 3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1, 4-benzodiazepin-3-yl]-3-(3-methylphenyl)-urea (YM022) の結晶形の検討および溶解性, 吸収性改善について. 薬誌. 1996, 116, 639-646

Terms in the title (5)： 製剤 ,  添加剤 ,  難溶性薬物 ,  溶媒 ,  分子間相互作用