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J-GLOBAL ID：200902193060682431   Reference number：03A0049936

Functional Tolerance of Streptomyces Subtilisin Inhibitor toward Conformational and Stability Changes Caused by Single-Point Mutations in the Hydrophobic Core.

Streptomycesスブチリシンインヒビターの疎水性コアの点突然変異によりもたらされた配座転移及び安定性変化に対するこのインヒビターの機能的寛容性

Author (8)： ODA M (Tokyo Univ. Sci., Chiba) ,  TAMURA A (Kobe Univ., Kobe) ,  KANAORI K (Kyoto Inst. Technol., Kyoto) ,  KOJIMA S (Gakushuin Univ., Tokyo) ,  MIURA K (Gakushuin Univ., Tokyo) ,  MOMMA K (Kyoto Univ., Kyoto) ,  TONOMURA B (Kyoto Univ., Kyoto) ,  AKASAKA K (Kinki Univ., Wakayama)
Material： Journal of Biochemistry  (J Biochem)
Volume： 132  Issue： 6  Page： 991-995  Publication year： Dec. 01, 2002 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibition ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (2)： Enzyme in general  (EB09010D) ,  Microorganism biochemistry  (EG03020N)

Reference (31)：

• TERABE, M. New subtilisin-trypsin inhibitors produced by Streptomyces : primary structures and their relationship to other proteinase inhibitors from Streptomyces. Biochim. Biophys. Acta. 1996, 1292, 233-240
• MURAO, S. Isolation of alkaline pretease inhibitor producing microorganisms. Agric. Biol. Chem. 1972, 36, 1737-1744
• HIROMI, K. Protein Protease Inhibito-The Case of Streptomyces Subtilisin Inhibitor. 1985
• MITSUI, Y. Crystal structure of a bacterial protein proteinase inhibitor (Streptomyces subtilisin inhibitor) at 2.6 A resolution. J. Mol. Biol. 1979, 131, 697-724
• TAKEUCHI, Y. Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 A resolution. J. Mol. Biol. 1991, 221, 309-325

Terms in the title (7)： Streptomyces ,  疎水性 ,  コア ,  点突然変異 ,  配座転移 ,  安定性 ,  インヒビター