Art

J-GLOBAL ID：200902194152730285   Reference number：02A0022583

Relationship between Solubility of Grifolan, a Fungal 1,3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro.

グリフォランの物性とマクロファージ培養系からのTNF産生能の関連

Author (5)： ISHIBASHI K (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  MIURA N N (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  ADACHI Y (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  OHNO N (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  YADOMAE T (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 65  Issue： 9  Page： 1993-2000  Publication year： Sep. 23, 2001 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Polyporaceae ,...
Semi thesaurus term： Grifola frondosa

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JST classification (2)： Biological function  (EB06020T) ,  Substance production by microorganisms,cultured tissues/cells in general  (FK03010P)

Reference (29)：

• 1) Yadomae, T. and Ohno, N., Structure-activity relationship of immunomodulating 1,3-β-D-glucans. Recent Research Develop. Chem. Pharm. Sciences, 1, 23-33 (1996).
• 2) Ohno, N., Iino, K., Takeyama, I., Suzuki, I., Sato, K., Oikawa, S., Miyazaki, T., and Yadomae, T., Structural characterization and antitumor activity of the extracts from matted mycelium of cultured Grifola frondosa. Chem. Pharm. Bull., 33, 2564-2568 (1985).
• 3) Ohno, N., Adachi, Y., Suzuki, I., Sato, K., Oikawa, S., and Yadomae, T., Characterization of the antitumor glucan obitained from liquid-cultured Grifola frondosa. Chem. Pharm. Bull., 34, 1709-1715 (1986).
• 4) Adachi, Y., Ohno, N., Yadomae, T., Ohsawa, M., and Oikawa, S., Thermal denaturation of 1,3-β-D-glucans in neutral aqueous solution above 130°C: Effect on physicochemical properties. Carbohydr. Res., 198, 111-122 (1990).
• 5) Okazaki, M., Adachi, Y., Ohno, N., and Yadomae, T., Structure-activity relationship of 1,3-β-D-glucans in the induction of cytokine production from macrophages, in vitro. Biol. Pharm. Bull., 18, 1320-1327 (1995).

Terms in the title (5)： 物性 ,  マクロファージ ,  培養 ,  TNF ,  能