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J-GLOBAL ID：200902206935516934   Reference number：03A0058872

消化管疾患の分子標的治療 GISTにおけるc-kit遺伝子の機能獲得性突然変異と分子標的治療

Author (1)： HIROTA SEIICHI (大阪大 医 病院 病理部)
Material： 日本消化器病学会雑誌  (Journal of Japanese Society of Gastroenterology)
Volume： 100  Issue： 1  Page： 13-20  Publication year： Jan. 05, 2003 
JST Material Number： F0892A  ISSN： 0446-6586  CODEN： NIPAA  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *digestive system tumor ,...
Semi thesaurus term： GIST ,...

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JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (21)：

• 1) Maeda H, Yamagata A, Nishikawa S, et al : Requirement of c-kit for development of Intestinal pacemaker system. Development 1992; 116: 369-375
• 2) Hirota S, Isozaki K, Moriyama Y, et al : Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279: 577-580
• 3) Isozaki K, Hirota S, Nakama A, et al : Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Gastroenterology 1995; 109: 456-464
• 4) Thomsen L, Robinson TL, Lee JCF, et al : Interstitial cells of Cajal generate a rhythmic pacemaker current. Nature Med 1998; 4 : 848-851
• 5) Furitsu T, Tsujimura T, Tono T, et al : Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit. J Clin Invest 1993; 92: 1736-1744

Terms in the title (5)： 消化管疾患 ,  分子標的治療 ,  GIST ,  c-kit遺伝子 ,  突然変異