Art

J-GLOBAL ID：200902207124147510   Reference number：04A0760115

Antisense phosphorothioate oligonucleotides to NF-κB (RelA/NF-κB1) decrease interleukin-8 secretion from cultured normal human epidermal keratinocytes

NF-κB(RelA/NF-κB1)に対するアンチセンスホスホロチオエートオリゴヌクレオチドは正常ヒト培養表皮ケラチン細胞からのインターロイキン8分泌を減少させる

Author (8)： IKEDA M (Kochi Univ., Kochi, JPN) ,  HIROSE Y (Kochi Univ., Kochi, JPN) ,  HAMADA R (Kochi Univ., Kochi, JPN) ,  NAKAJIMA H (Kochi Univ., Kochi, JPN) ,  MIYOSHI K (Kochi Univ., Kochi, JPN) ,  MATSUMOTO M (Kochi Univ., Kochi, JPN) ,  SEIKE M (Kochi Univ., Kochi, JPN) ,  KODAMA H (Kochi Univ., Kochi, JPN)
Material： Journal of Dermatological Science  (J Dermatol Sci)
Volume： 35  Issue： 3  Page： 230-232  Publication year： Sep. 2004 
JST Material Number： W1280A  ISSN： 0923-1811  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antisense nucleotide ,...
Semi thesaurus term： RelA ,...

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JST classification (1)： Basic dermatology  (GF01020Y)

Substance index (1)： Phorbol 12-myristate 13-acetate

Reference (9)：

• NOONBERG, SB. Characteristics of oligonucleotide uptake in human keratinocyte cultures. J Invest Dermatol. 1993, 101, 727-731
• SOKOLOSKI, JA. Antisense oligonucleotides to the p65 subunit of NF-κB block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes. Blood. 1993, 82, 625-632
• KUNSCH, C. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6. J Immunol. 1994, 153, 153-164
• OKAMOTO, S. The interleukin-8 AP-1 and κB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. J Biol Chem. 1994, 269, 8582-8589
• STEIN, B. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol Cell Biol. 1993, 13, 7191-7198

Terms in the title (8)： NF-κB ,  RelA ,  NF-κB1 ,  ヒト ,  培養表皮 ,  ケラチン細胞 ,  インターロイキン8 ,  分泌