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J-GLOBAL ID：200902207877305010   Reference number：08A0285885

Progress in Allergy Signal Research on Mast Cells: The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation - a Study Using the Hdc Knockout Mouse

肥満細胞のアレルギーシグナル研究の進歩:アレルギー性気道炎症の杯細胞過形成におけるヒスタミンの役割 -Hdcノックアウトマウスを用いる研究

Author (14)： YAMAUCHI Kohei (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  PIAO Hong Mei (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  PIAO Hong Mei (Dep. of Respiratory Medicine, Affiliated Hospital of Yanbian Univ. Coll. of Medicine, CHN) ,  NAKADATE Toshihide (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  SHIKANAI Toshiki (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  NAKAMURA Yutaka (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  NIISATO Miyuki (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  ITO Harumasa (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  MOURI Takashi (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  KOBAYASHI Hitoshi (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN) ,  MAESAWA Chihaya (Second Dep. of Pathology, Iwate Medical Univ. School of Medicine, JPN) ,  SAWAI Takashi (First Dep. of Pathology, Iwate Medical Univ. School of Medicine, JPN) ,  OHTSU Hiroshi (Tohoku Univ. Graduate School of Engineering, JPN) ,  INOUE Hiroshi (Third Dep. of Internal Medicine, Iwate Medical Univ. School of Medicine, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 106  Issue： 3  Page： 354-360 (J-STAGE)  Publication year： 2008 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： epithelial cell ,...
Semi thesaurus term： BALF ,...

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JST classification (3)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Biological function  (EB02020R) ,  Gene manipulation  (EC02050B)

Substance index (1)： Histamine

Reference (39)：

• LAITINEN, A. Pathology of asthma. Allergy Proc. 1994, 15, 323-328
• SHIMURA, S. Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. Eur Respir J. 1996, 9, 1395-1401
• CARROLL, N. Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J. 1996, 9, 709-715
• AIKAWA, T. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest. 1992, 101, 916-921
• VOYNOW, JA. Neutrophil elastase induces mucus cell metaplasia in mouse lung. Am J Physiol Lung Cell Mol Physiol. 2004, 287, L1293-L1302

Terms in the title (11)： 肥満細胞 ,  アレルギー ,  シグナル ,  研究 ,  アレルギー性気道炎症 ,  杯細胞 ,  過形成 ,  ヒスタミン ,  役割 ,  HDC ,  ノックアウトマウス