Art

J-GLOBAL ID：200902208586975147   Reference number：03A0197381

A Facile Synthesis of 1,1-Disubstituted 1,2,3,4-Tetrahydro-β-carbolines via Trifluoroacetic Acid Catalyzed Pictet-Spengler Reaction Using Titanium(IV) Isopropoxide as an Imination Reagent.

イミノ化試薬としてチタン(IV)イソプロポキシドを用いたトリフルオロ酢酸触媒Pictet-Spengler反応を経由する1,1-二置換1,2,3,4-テトラヒドロ-β-カルボリンの容易な合成

Author (6)： HORIGUCHI Y (Showa Pharmaceutical Univ., Tokyo, JPN) ,  NAKAMURA M (Showa Pharmaceutical Univ., Tokyo, JPN) ,  KIDA A (Showa Pharmaceutical Univ., Tokyo, JPN) ,  KODAMA H (Showa Pharmaceutical Univ., Tokyo, JPN) ,  SAITOH T (Showa Pharmaceutical Univ., Tokyo, JPN) ,  SANO T (Showa Pharmaceutical Univ., Tokyo, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 59  Issue： 2  Page： 691-705  Publication year： Mar. 01, 2003 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： one-pot synthesis ,...

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JST classification (1)： Other condensed derivatives of pyridine  (CF07097Y)

Substance index (29)： Trifluoroacetic Acid ,  Tryptamine ,  Acetophenone ,  Acetone ,  Methyl ethyl ketone ,  Benzophenone ,  Cyclopentanone ,  Cyclohexanone ,  Indan-1-one ,  Titanium(IV)tetraisopropoxide ,  1-(Phenylthio)-2-propanone ,  1-Methyl-1-phenyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  1,1-Dimethyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  1-Methyl-1-ethyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  1-Methyl-1-[(phenylthio)methyl]-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  1,1-Diphenyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-cyclopentane]-2-carbaldehyde ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-cyclohexane]-2-carbaldehyde ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-indan]-2-carbaldehyde ,  6-Acetyl-1-methyl-1-phenyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde ,  1-Methyl-1-phenyl-1,2,3,4-tetrahydro-β-carboline ,  1,1-Dimethyl-1,2,3,4-tetrahydro-β-carboline ,  1-Methyl-2-ethyl-1,2,3,4-tetrahydro-β-carboline ,  1-Methyl-1-[(phenylthio)methyl]-1,2,3,4-tetrahydro-β-carboline ,  1,1-Diphenyl-1,2,3,4-tetrahydro-β-carboline ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-cyclopentane] ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-cyclohexane] ,  3,4-Dihydrospiro[β-carboline-1(2H),1′-indan] ,  6-Acetyl-1,1-dimethyl-3,4-dihydro-β-carboline-2(1H)-carbaldehyde

Terms in the title (9)： イミノ化 ,  試薬 ,  チタン ,  イソプロポキシド ,  トリフルオロ酢酸 ,  触媒 ,  Pictet-Spengler反応 ,  置換 ,  β-カルボリン