Art

J-GLOBAL ID：200902209633792001   Reference number：09A0716187

Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus

舌及び食道において全体的DNA低メチル化は扁平上皮癌発症を抑制する

Author (8)： BABA Seiji (Gifu Univ. Graduate School of Medicine, Gifu) ,  YAMADA Yasuhiro (Gifu Univ. Graduate School of Medicine, Gifu) ,  YAMADA Yasuhiro (JST-PRESTO, Saitama, JPN) ,  HATANO Yuichiro (Gifu Univ. Graduate School of Medicine, Gifu) ,  MIYAZAKI Yasuo (Gifu Univ. Graduate School of Medicine, Gifu) ,  MORI Hideki (Gifu Univ. Graduate School of Medicine, Gifu) ,  SHIBATA Toshiyuki (Gifu Univ. Graduate School of Medicine, Gifu) ,  HARA Akira (Gifu Univ. Graduate School of Medicine, Gifu)
Material： Cancer Science  (Cancer Sci)
Volume： 100  Issue： 7  Page： 1186-1191  Publication year： Jul. 2009 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： tongue neoplasm ,...
Semi thesaurus term： *DNA Methylation ,...

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JST classification (1)： Carcinogenic mechanisms and factors  (GE02020C)

Substance index (1)： 4-Nitroquinoline-1-oxide

Reference (25)：

• JONES, PA. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002, 3, 415-428
• CHEN, RZ. DNA hypomethylation leads to elevated mutation rates. Nature. 1998, 395, 89-93
• TOYOTA, M. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999, 96, 8681-8686
• YAMADA, Y. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci USA. 2005, 102, "13 580"-"13 585"
• LAIRD, PW. Suppression of intestinal neoplasia by DNA hypomethylation. Cell. 1995, 81, 197-205

Terms in the title (6)： 舌 ,  食道 ,  DNA ,  低メチル化 ,  扁平上皮癌 ,  発症