In vitro conversion of irinotecan to SN-38 in human plasma

SHINGYOJI M; TAKIGUCHI Y; WATANABE-URUMA R; ASAKA-AMANO Y; MATSUBARA H; KUROSU K; KASAHARA Y; TANABE N; TATSUMI K

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J-GLOBAL ID：200902209900848526 Reference number：04A0442981

In vitro conversion of irinotecan to SN-38 in human plasma

ヒト血しょうにおけるイリノテカンのSN-38へのin vitro変換

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Material：
Volume： 95 Issue： 6 Page： 537-540 Publication year： Jun. 10, 2004
JST Material Number： F0633A ISSN： 1347-9032 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic biopharmacy

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KANZAWA, F. Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer : characterization and mechanism of resistance. Cancer Res. 1990, 50, 5919-5924
KAWATO, Y. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991, 51, 4187-4191
MATHIJSSEN, RH. Clinical pharmacokinetics and metabolism of irinotecan (cpt-11). Clin Cancer Res. 2001, 7, 2182-2194
SASAKI, Y. A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38. Jpn J Cancer Res. 1995, 86, 101-110

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