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J-GLOBAL ID：200902213365539168   Reference number：05A0663614

Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells

ニガウリの種子脂肪酸は9c,11t,13t共役リノレン酸が豊富であり,ヒト結腸癌Caco-2細胞でアポトーシスを誘導し,GADD45,p53とPPARγをアップレギュレーションする

Author (8)： YASUI Yumiko (Graduate School of Fisheries Sciences, Hokkaido Univ., 3-1-1 Minato, Hakodate, Hokkaido 041-8611, JPN) ,  HOSOKAWA Masashi (Graduate School of Fisheries Sciences, Hokkaido Univ., 3-1-1 Minato, Hakodate, Hokkaido 041-8611, JPN) ,  SAHARA Takehiko (Res. Inst. of Genome-based Biofactory, National Inst. of Advanced Industrial Sci. and Technol. (AIST), 2-17-2-1 ...) ,  SUZUKI Rikako (Res. Inst. of Genome-based Biofactory, National Inst. of Advanced Industrial Sci. and Technol. (AIST), 2-17-2-1 ...) ,  OHGIYA Satoru (Res. Inst. of Genome-based Biofactory, National Inst. of Advanced Industrial Sci. and Technol. (AIST), 2-17-2-1 ...) ,  KOHNO Hiroyuki (Dep. of Oncologic Pathology, Kanazawa Medical Univ., 1-1 Daigaku, Uchinada, Ishikawa 920-0293, JPN) ,  TANAKA Takuji (Dep. of Oncologic Pathology, Kanazawa Medical Univ., 1-1 Daigaku, Uchinada, Ishikawa 920-0293, JPN) ,  MIYASHITA Kazuo (Graduate School of Fisheries Sciences, Hokkaido Univ., 3-1-1 Minato, Hakodate, Hokkaido 041-8611, JPN)
Material： Prostaglandins, Leukotrienes and Essential Fatty Acids  (Prostaglandins Leukotrienes and Essential Fatty Acids)
Volume： 73  Issue： 2  Page： 113-119  Publication year： Aug. 2005 
JST Material Number： C0739A  ISSN： 0952-3278  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Cucurbitaceae ,...
Semi thesaurus term： ゴーヤ ,...

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JST classification (3)： Vegetables and processed vegetable products  (FJ11020O) ,  Edible fats and oils,margarines  (FJ09010C) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (1)： Linolenic acid

Terms in the title (13)： ニガウリ ,  種子 ,  脂肪酸 ,  共役リノレン酸 ,  ヒト ,  結腸癌 ,  Caco-2細胞 ,  アポトーシス ,  誘導 ,  GADD45 ,  p53 ,  PPARγ ,  アップレギュレーション