Art

J-GLOBAL ID：200902220045897364   Reference number：05A0565584

Macrophage inflammatory protein-1α plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice

マクロファージの炎症性プロテイン-1αはマウスに於ける炎症誘発性のサイトカインの誘導を通してコンカナバリンAが誘発する肝障害に於いて重大な役割を演ずる

Author (5)： OKAMOTO Satoshi (Second Dep. of Medicine, Asahikawa Medical Coll., Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, JPN) ,  YOKOHAMA Shiro (Second Dep. of Medicine, Asahikawa Medical Coll., Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, JPN) ,  YONEDA Masashi (Dep. of Gastroenterology, Dokkyo Univ. School of Medicine, Mibu, JPN) ,  HANEDA Masakazu (Second Dep. of Medicine, Asahikawa Medical Coll., Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, JPN) ,  NAKAMURA Kimihide (Second Dep. of Medicine, Asahikawa Medical Coll., Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, JPN)
Material： Hepatology Research  (Hepatol Res)
Volume： 32  Issue： 1  Page： 38-45  Publication year： May. 2005 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *liver disease ,...

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JST classification (1)： Basic medicine on digestive system  (GH01020E)

Reference (50)：

• TIEGS, G. T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest. 1992, 90, 196-203
• KNOLLE, PA. Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice. Hepatology. 1996, 24, 824-829
• FUJIKURA, S. Kinetics and localization of lymphoblasts that proliferate in the murine liver after concanavalin A administration. Biomed Res. 1996, 17, 129-139
• MIZUHARA, H. T cell activation-associated hepatic injury : mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med. 1994, 179, 1529-1537
• GANTNER, F. Concanavalin A-induced T-cell-mediated hepatic injury in mice : the role of tumor necrosis factor. Hepatology. 1995, 21, 190-198

Terms in the title (10)： マクロファージ ,  炎症 ,  プロテイン ,  マウス ,  サイトカイン ,  誘導 ,  コンカナバリンA ,  誘発 ,  肝障害 ,  役割