Art

J-GLOBAL ID：200902221844800280   Reference number：03A0472065

Physicochemical and Crystal Structure Analyses of the Antidiabetic Agent Troglitazone

抗糖尿病薬,トログリタゾンの物理化学的性質及び結晶構造解析

Author (6)： KOBAYASHI K (Sankyo Co., Ltd., Kanagawa, JPN) ,  FUKUHARA H (Sankyo Co., Ltd., Kanagawa, JPN) ,  HATA T (Sankyo Co., Ltd., Tokyo, JPN) ,  SEKINE A (Tokyo Inst. of Technol., Tokyo, JPN) ,  UEKUSA H (Tokyo Inst. of Technol., Tokyo, JPN) ,  OHASHI Y (Tokyo Inst. of Technol., Tokyo, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 51  Issue： 7  Page： 807-814  Publication year： Jul. 01, 2003 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *oxygen heterocyclic compound ,...
Semi thesaurus term： mixed crystal

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JST classification (3)： Condensed derivatives of pyrane  (CF07093I) ,  Physicochemical characteristics of drugs  (GV01060M) ,  Crystal structure of heterocyclic compounds  (BK08030Q)

Substance index (5)： Troglitazone ,  (5R)-5β-[4-[[(2R)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2β-yl]methyl]benzyl]thiazolidine-2,4-dione ,  (5S)-5α-[4-[[(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2α-yl]methyl]benzyl]thiazolidine-2,4-dione ,  (5S)-5α-[4-[[(2R)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2β-yl]methyl]benzyl]thiazolidine-2,4-dione ,  (5R)-5β-[4-[[(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2α-yl]methyl]benzyl]thiazolidine-2,4-dione

Reference (19)：

• 1) Haleblian J. K., McCrone W., J. Pharm. Sci., 58, 911—929 (1969).
• 2) Haleblian J. K., J. Pharm. Sci., 64, 1269—1288 (1975).
• 3) Byrn S. R., “Solid-state Chemistry of Drugs,” Academic Press, New York, 1982.
• 4) Borka L., Pharm. Acta Helv., 66, 16—22 (1991).
• 5) Sugi K., Itaya N., Katsura T., Igi, M., Yamazaki S., Ishibashi T., Yamaoka T., Kawada Y., Tagami Y., Otsuki M., Ohshima T., Chem. Pharm. Bull., 48, 529—536 (2000).

Terms in the title (4)： 抗糖尿病薬 ,  トログリタゾン ,  物理化学的性質 ,  結晶構造解析