A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions.

KASHIWAZAKI M; TANAKA T; KANDA H; EBISUNO Y; IZAWA D; FUKUMA N; AKIMITSU N; SEKIMIZU K; MIYASAKA M

Art

J-GLOBAL ID：200902225690581047 Reference number：03A0712704

A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions.

高内皮小静脈が発現する無差別なケモカイン受容体DARCはリンパ系ではない炎症性ケモカインに結合し,生理的条件下のリンパ球ホーミングに必要ではない

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Material：
Volume： 15 Issue： 10 Page： 1219-1227 Publication year： Oct. 2003
JST Material Number： W0116A ISSN： 0953-8178 Document type： Article
Article type：原著論文 Country of issue： United Kingdom (GBR) Language： ENGLISH (EN)

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Immunological reaction in general

Reference (45)：

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SPRINGER, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration : the multistep paradigm. Cell. 1994, 76, 301
CONSTANTIN, G. Chemokines trigger immediate β_2 integrin affinity and mobility changes : differential regulation and roles in lymphocyte arrest under flow. Immunity. 2000, 13, 759

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