Art

J-GLOBAL ID：200902228657839160   Reference number：08A0381311

Mechanisms Responsible for Reduced Cardiotoxicity of Mitoxantrone Compared to Doxorubicin Examined in Isolated Guinea-Pig Heart Preparations

モルモット摘出心筋標本におけるミトキサントロンのドキソルビシンと比較した低心毒性作用の機序

Author (9)： CHUGUN Akihito (Kitasato Univ., Aomori, JPN) ,  UCHIDE Tsuyoshi (Kitasato Univ., Aomori, JPN) ,  TSURIMAKI Chieko (Kitasato Univ., Aomori, JPN) ,  NAGASAWA Hajime (Kitasato Univ., Aomori, JPN) ,  SASAKI Takushi (Kitasato Univ., Aomori, JPN) ,  UENO Shunji (Kitasato Univ., Aomori, JPN) ,  TAKAGISHI Kiyohiko (Kitasato Univ., Aomori, JPN) ,  HARA Yukio (Kitasato Univ., Aomori, JPN) ,  TEMMA Kyosuke (Kitasato Univ., Aomori, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 70  Issue： 3  Page： 255-264  Publication year： Mar. 25, 2008 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *guinea pig ,...
Semi thesaurus term： anticancer drug ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Heart  (EJ04020D)

Substance index (3)： Mitoxantrone ,  Doxorubicin ,  Caffeine

Reference (37)：

• BAYER, R. Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardium. Naunya-Schmiedberg's. Arch. Pharmacol. 1975, 290, 49-68
• BENJAMIN, R. S. Rationale for the use of mitoxantrone in the older patient : cardiac toxicity. Seminars in Oncol. 1995, 22, Suppl., 11-13
• BERS, D. M. A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions. Am. J. Physiol. 1982, 242, C404-C408
• BERS, D. M. Ca influx and sarcoplasmic reticulum Ca release in cardiac muscle activation during postrest recovery. Am. J. Physiol. 1985, 248, H366-H381
• BERS, D. M. Na/Ca exchange and the sarcolemmal Ca-pump. Excitation-Contraction Coupling and Cardiac Contractile Force. 2001, 133-160

Terms in the title (7)： モルモット ,  摘出心 ,  標本 ,  ミトキサントロン ,  ドキソルビシン ,  心 ,  毒性作用