Art

J-GLOBAL ID：200902230021353113   Reference number：08A0824074

Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1

TAK1架橋によるNF-κB発信を阻害する自然発生ペンタケタイド二量体のエポキシキノールB

Author (9)： KAMIYAMA Hiroshi (Antibiotics Lab., RIKEN Advanced Sci. Inst.) ,  KAMIYAMA Hiroshi (Graduate School of Sci. and Engineering, Saitama Univ.) ,  USUI Takeo (Graduate School of Life and Environmental Sciences, Univ. of Tsukuba) ,  SAKURAI Hiroaki (Div. of Pathogenic Biochemistry, Inst. of Natural Medicine, Univ. of Toyama) ,  SHOJI Mitsuru (Dep. of Industrial Chemistry, Fac. of Engineering, Tokyo Univ. of Sci.) ,  HAYASHI Yujiro (Dep. of Industrial Chemistry, Fac. of Engineering, Tokyo Univ. of Sci.) ,  KAKEYA Hideaki (Antibiotics Lab., RIKEN Advanced Sci. Inst.) ,  OSADA Hiroyuki (Antibiotics Lab., RIKEN Advanced Sci. Inst.) ,  OSADA Hiroyuki (Graduate School of Sci. and Engineering, Saitama Univ.)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 72  Issue： 7  Page： 1894-1900 (J-STAGE)  Publication year： 2008 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： DNA microarray ,...
Semi thesaurus term： microarray ,...

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JST classification (1)： Cell physiology in general  (EF02010S)

Reference (22)：

• BREMNER, P. Natural products as targeted modulators of the nuclear factor-κB pathway. J. Pharm. Pharmacol. 2002, 54, 453-472
• ARIGA, A. Inhibition of tumor necrosis factor-α-induced nuclear translocation and activation of NF-κB by dehydroxymethylepoxyquinomicin. J. Biol. Chem. 2002, 277, 24625-24630
• LIANG, M. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor κB by inhibiting the inhibitor of κB kinase. Mol. Pharmacol. 2003, 64, 123-131
• KWOK, B. H. The anti-inflammatory natural product parthenolide from the medical herb feverfew directly binds to and inhibits IκB kinase. Chem. Biol. 2001, 8, 759-766
• BERNIER, M. Binding of manumycin A inhibits IκB kinase β activity. J. Biol. Chem. 2006, 281, 2551-2561

Terms in the title (6)： TAK1 ,  架橋 ,  NF-κB ,  阻害 ,  二量体 ,  エポキシキノールB