Art

J-GLOBAL ID：200902232496734050   Reference number：08A0586111

Stereoselective Oxidation and Glucuronidation of Carvedilol in Human Liver and Intestinal Microsomes

ヒト肝と腸ミクロソームにおけるカルベジロールの立体選択的酸化とグルクロン酸化

Author (6)： ISHIDA Kazuya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  TAIRA Shigehiro (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  MORISHITA Hiroki (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  KAYANO Yuichiro (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  TAGUCHI Masato (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  HASHIMOTO Yukiya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 31  Issue： 6  Page： 1297-1300 (J-STAGE)  Publication year： 2008 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： stereospecific reaction ,...
Semi thesaurus term： CYP1A2 ,...

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JST classification (3)： Drugs acting on circulatory system in general  (GW07010C) ,  Basic biopharmacy  (GY01021U) ,  Enzyme physiology  (EJ02020P)

Substance index (8)： (R)-Carvedilol ,  (S)-Carvedilol ,  NADPH ,  UDP-glucuronic acid ,  Carvedilol ,  Quinidine ,  Ketoconazole ,  Furafylline

Reference (16)：

• 1) Packer M., Bristow M. R., Cohn J. N., Colucci W. S., Fowler M. B., Gilbert E. M., Shusterman N. H., N. Engl. J. Med., 334, 1349—1355 (1996).
• 2) Eggertsen R., Sivertsson R., Andren L., Hansson L., J. Cardiovasc. Pharmacol., 10 (Suppl. 11), S97—S100 (1987).
• 3) Nagele H., Bohlmann M., Eck U., Petersen B., Rodiger W., Eur. J. Heart Fail., 2, 71—79 (2000).
• 4) Nahrendorf W., Rading A., Steinig G., van der Does R., Schlote A., J. Cardiovasc. Pharmacol., 19 (Suppl. 1), S114—S116 (1992).
• 5) Honda M., Nozawa T., Igarashi N., Inoue H., Arakawa R., Ogura Y., Okabe H., Taguchi M., Hashimoto Y., Biol. Pharm. Bull., 28, 1476—1479 (2005).

Terms in the title (8)： ヒト ,  肝 ,  腸 ,  ミクロソーム ,  カルベジロール ,  立体 ,  選択的酸化 ,  グルクロン酸化