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J-GLOBAL ID：200902234986907893   Reference number：09A0895952

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

cAMPセンサーEpac2は,スルフォニルウレア系抗糖尿病薬の直接的標的である

Author (11)： ZHANG Chang-Liang (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  KATOH Megumi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SHIBASAKI Tadao (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  MINAMI Kohtaro (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SUNAGA Yasuhiro (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  TAKAHASHI Harumi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  YOKOI Norihide (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  IWASAKI Masahiro (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  MIKI Takashi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SEINO Susumu (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SEINO Susumu (JST-CREST, Saitama, JPN)
Material： Science
Volume： 325  Issue： 5940  Page： 607-610  Publication year： Jul. 31, 2009 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： hypoglycemic drug ,  *hypoglycemic action ,  GTP binding protein ,  *protein ,  fluorescence resonance energy transfer ,  deletion mutation ,  mouse(animal) ,  internal secretion ,  *target ,  intermolecular interaction ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide ,  amine ,  aromatic compound ,  sulfonamide ,  urea compound
Semi thesaurus term： sulphonylurea agent ,  *Epac2 ,  *antidiabetic action ,  Rap1 ,  GAP protein ,  insulin secretion

JST classification (2)： Cell components in general  (EF03010Z) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (2)： cAMP ,  Tolbutamide

Terms in the title (6)： cAMP ,  センサー ,  Epac2 ,  スルフォニルウレア ,  抗糖尿病薬 ,  標的