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J-GLOBAL ID：200902240844998603   Reference number：08A0904265

A Novel Splice Variant of the Nuclear Coactivator p120 Functions Strongly for Androgen Receptor: Characteristic Expression in Prostate Disease

核内コアクチベータp120の新規スプライスバリアントはアンドロゲン受容体に対し強く機能する:前立腺疾患における特徴的発現

Author (8)： HOSOYA Takeshi (Dep. of Medicine and Molecular Sci., Gunma Univ. Graduate School of Medicine) ,  MONDEN Tsuyoshi (Dep. of Endocrinology and Metabolism, Dokkyo Univ. School of Medicine) ,  FUKABORI Yoshitatsu (Dep. of Urology, Dokkyo Univ. School of Medicine) ,  HASHIMOTO Koshi (Dep. of Medicine and Molecular Sci., Gunma Univ. Graduate School of Medicine) ,  SATOH Teturou (Dep. of Medicine and Molecular Sci., Gunma Univ. Graduate School of Medicine) ,  KASAI Kikuo (Dep. of Endocrinology and Metabolism, Dokkyo Univ. School of Medicine) ,  YAMADA Masanobu (Dep. of Endocrinology and Metabolism, Dokkyo Univ. School of Medicine) ,  MORI Masatomo (Dep. of Medicine and Molecular Sci., Gunma Univ. Graduate School of Medicine)
Material： Endocrine Journal  (Endocr J)
Volume： 55  Issue： 4  Page： 657-665 (J-STAGE)  Publication year： 2008 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *mutant ,...
Semi thesaurus term： coupling factor ,...

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JST classification (3)： Biological function  (EB03040U) ,  Molecular genetics in general  (EC02010J) ,  Basic medicine on urogenital system  (GM01020T)

Substance index (1)： Glutamine

Reference (36)：

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• 3. Klotz L. (2000) Hormone therapy for patients with prostate carcinoma. Cancer 88: 3009-30014.
• 4. Taplin M-E, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK, Keer HN, Balk SP (1995) Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 332: 1393-1398.
• 5. Mononen N, Syrjäkoski K, Matikainen M, Tammela TLJ, Schleukter J, Kallioniemi O-P, Trapman J, Koivisto PA (2000) Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene. Cancer Res 60: 6479-6481.

Terms in the title (6)： コアクチベータ ,  p120 ,  スプライスバリアント ,  アンドロゲン受容体 ,  前立腺疾患 ,  発現