Art

J-GLOBAL ID：200902241360773425   Reference number：09A0225914

A New Synthetic Compound, SST-VEDI-1, Inhibits Osteoblast Differentiation with a Down-Regulation of the Osterix Expression

新合成化合物,SST-VEDI-1は,Osterixの発現のダウンレギュレーションで骨芽細胞分化を阻害する

Author (3)： MIKAMI Yoshikazu (Nihon Univ. School of Dentistry, Tokyo, JPN) ,  SOMEI Masanori (Kanazawa Univ., Ishikawa, JPN) ,  TAKAGI Minoru (Nihon Univ. School of Dentistry, Tokyo, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 145  Issue： 2  Page： 239-247  Publication year： Feb. 01, 2009 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *protein ,...
Semi thesaurus term： Dlx gene ,...

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JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic research of other drugs  (GW23010K)

Substance index (3)： SST-VEDI ,  SSH-BMI ,  N-[2-(1-Tosyl-2,4,6-tribromo-5-methoxy-1H-indole-3-yl)ethyl]acetamide

Reference (34)：

• SOMEI, M. Definitions of IPF and APF. Heterocycles. 2004, 64, 483
• SOMEI, M. The ideal synthetic method aimed at the leads for an α_2-BLOCKR, an inhibitor of blood platelet aggregation, and an anti-osteoporosis agent. Heterocycles. 2006, 68, 1565-1569
• GRANDY, D. K. Trace amine-associated receptor 1-Family archetype or iconoclast?. Pharmacol. Ther. 2007, 116, 355-390
• ZUCCHI, R. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 2006, 149, 967-978
• SUZUKI, N. Novel bromomelatonin derivatives suppress osteoclastic activity and increase osteoblastic activity : implications for the treatment of bone diseases. J. Pineal Res. 2008, 44, 326-334

Terms in the title (6)： SST ,  osterix ,  発現 ,  ダウンレギュレーション ,  骨芽細胞分化 ,  阻害