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J-GLOBAL ID：200902243522640087   Reference number：06A0516343

Molecular Mechanism for Pterin-Mediated Inactivation of Tyrosine Hydroxylase: Formation of Insoluble Aggregates of Tyrosine Hydroxylase

チロシンヒドロキシラーゼのプテリン仲介不活性化の分子メカニズム:チロシンヒドロキシラーゼの不溶性凝集体の形成

Author (7)： URANO Fumi (Tokyo Inst. of Technol., Yokohama) ,  URANO Fumi (Japan Assoc. Advancement of Medical Equipment, Tokyo) ,  HAYASHI Nobuhiro (Fujita Health Univ., Toyoake) ,  ARISAKA Fumio (Tokyo Inst. of Technol., Yokohama) ,  KURITA Hideki (Fujita Health Univ., Toyoake) ,  MURATA Shizuaki (Nagoya Univ., Nagoya) ,  ICHINOSE Hiroshi (Tokyo Inst. of Technol., Yokohama)
Material： Journal of Biochemistry  (J Biochem)
Volume： 139  Issue： 4  Page： 625-635  Publication year： Apr. 01, 2006 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tyrosine hydroxylase ,...
Semi thesaurus term： Pterins

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JST classification (2)： Enzyme in general  (EB09010D) ,  Animal biochemistry  (EJ01050P)

Substance index (3)： Tetrahydrobiopterin ,  Biopterin ,  Dopamine

Reference (40)：

• NAGATSU, T. Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J. Biol. Chem. 1964, 239, 2910-2917
• LEVITT, M. Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused Guinea-pig heart. J. Pharmacol. Exp. Ther. 1965, 148, 1-8
• ANDERSSON, K. K. Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). J. Biol. Chem. 1988, 263, 18621-18626
• OKUNO, S. A new mechanism for regulation of tyrosine 3-monooxygenase by end product and cyclic AMP-dependent protein kinase. J. Biol. Chem. 1985, 260, 2633-2635
• MCCULLOCH, R. I. Limited proteolysis of tyrosine hydroxylase identifies residues 33-50 as conformationally sensitive to phosphorylation state and dopamine binding. Arch. Biochem. Biophys. 1999, 367, 143-145

Terms in the title (7)： チロシンヒドロキシラーゼ ,  プテリン ,  仲介 ,  不活性化 ,  分子メカニズム ,  不溶性 ,  凝集体